Hidradenitis suppurativa (HS) is a chronic inflammatory skin disease caused by the obstruction of the hair follicle. It manifests in form of profound painful nodules and abscesses up to the formation of fistulas and sinus tracts. Areas involved in men and women are axillae, inguinal, gluteal and perianal whereby women can additionally be affected sub-mammary. 1 Many patients are smokers and suffer from comorbidities such as obesity, type 2-diabetes, chronic inflammatory bowel diseases and depression. This is associated with a considerable reduction of quality of life. 2,3 So far, the exact pathophysiological mechanisms underlying HS have not been understood completely. However, hyperkeratosis and perifolliculitis in the pilosebaceous-apocrine unit are assumed to precede the occlusion, inflammation and rupture of the hair follicle. [4][5][6] Subsequently, an increased inflammatory response due to the release of keratins,
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.