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The predefined principles were successfully integrated in the new algorithm. Thus, the algorithm switched more than 90% of the evaluated preadmission drugs to suitable drugs for inpatients with feeding tubes. This finding suggests that the algorithm can readily be transferred to an electronic format and integrated into a clinical decision support system.

Hidradenitis suppurativa (HS) is a chronic inflammatory skin disease caused by the obstruction of the hair follicle. It manifests in form of profound painful nodules and abscesses up to the formation of fistulas and sinus tracts. Areas involved in men and women are axillae, inguinal, gluteal and perianal whereby women can additionally be affected sub-mammary. 1 Many patients are smokers and suffer from comorbidities such as obesity, type 2-diabetes, chronic inflammatory bowel diseases and depression. This is associated with a considerable reduction of quality of life. 2,3 So far, the exact pathophysiological mechanisms underlying HS have not been understood completely. However, hyperkeratosis and perifolliculitis in the pilosebaceous-apocrine unit are assumed to precede the occlusion, inflammation and rupture of the hair follicle. [4][5][6] Subsequently, an increased inflammatory response due to the release of keratins,

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Chronic wounds exhibit elevated levels of inflammatory cytokines, resulting in the release of proteolytic enzymes which delay wound-healing processes. In recent years, rifampicin has gained significant attention in the treatment of chronic wounds due to an interesting combination of antibacterial and anti-inflammatory effects. Unfortunately, rifampicin is sensitive to hydrolysis and oxidation. As a result, no topical drug product for wound-healing applications has been approved. To address this medical need two nanostructured hydrogel formulations of rifampicin were developed. The liposomal vesicles were embedded into hydroxypropyl methylcellulose (HPMC) gel or a combination of hyaluronic acid and marine collagen. To protect rifampicin from degradation in aqueous environments, a freeze-drying method was developed. Before freeze-drying, two well-defined hydrogel preparations were obtained. After freeze-drying, the visual appearance, chemical stability, residual moisture content, and redispersion time of both preparations were within acceptable limits. However, the morphological characterization revealed an increase in the vesicle size for collagen–hyaluronic acid hydrogel. This was confirmed by subsequent release studies. Interactions of marine collagen with phosphatidylcholine were held responsible for this effect. The HPMC hydrogel formulation remained stable over 6 months of storage. Moving forward, this product fulfills all criteria to be evaluated in preclinical and clinical studies.