Mechanism of anti‐inflammatory effects of rifampicin in an ex vivo culture system of hidradenitis suppurativa

Abstract

Hidradenitis suppurativa (HS) is a chronic inflammatory skin disease caused by the obstruction of the hair follicle. It manifests in form of profound painful nodules and abscesses up to the formation of fistulas and sinus tracts. Areas involved in men and women are axillae, inguinal, gluteal and perianal whereby women can additionally be affected sub-mammary. 1 Many patients are smokers and suffer from comorbidities such as obesity, type 2-diabetes, chronic inflammatory bowel diseases and depression. This is associated with a considerable reduction of quality of life. 2,3 So far, the exact pathophysiological mechanisms underlying HS have not been understood completely. However, hyperkeratosis and perifolliculitis in the pilosebaceous-apocrine unit are assumed to precede the occlusion, inflammation and rupture of the hair follicle. [4][5][6] Subsequently, an increased inflammatory response due to the release of keratins,

Case of resolution of plaque psoriasis following treatment with rifampicin for latent tuberculosis: A case report

“… 8 For HS, anti-inflammatory effect was attributed to decreased production of IL-1β, IL-6, IL-8, IL-10, and TNF-α. 9 Hence, rifampicin may be an effective therapy in some patients with inflammatory skin diseases due to its immunomodulatory effects.…”

The PI3K-Akt-mTOR and Associated Signaling Pathways as Molecular Drivers of Immune-Mediated Inflammatory Skin Diseases: Update on Therapeutic Strategy Using Natural and Synthetic Compounds

“…Laser therapy, surgical removal, incision and drainage, lifestyle modification such as smoking cessation, controlling obesity, and dieting are all useful for HS management [ 235 ]. We have recently shown the anti-inflammatory effect of Rifampicin in ex vivo cultures of HS [ 243 ].…”

A Novel Epidermis Model Using Primary Hidradenitis Suppurativa Keratinocytes

“…For ex vivo studies, punch biopsies, so-called explants, are taken from lesional and nonlesional HS tissues and cultured in a transwell system with the epidermis exposed at the air-liquid interface. Tis system presents an ideal setup for basic research as well as drug and biomarker screening in the laboratory, as nearly all the characteristics of the native tissue are represented [9,[21][22][23][24][25][26][27][28][29][30]. Still debated is whether established animal models for other diseases, such as acne-like diseases, are also suitable as animal models for HS.…”