No abstract

The appendicular skeletons of high [C3H/HeJ (C3H)] and low [C57BL/6J (B6)] density inbred mice have been shown to differ in morphology, mechanical properties, and cellular activity. The focus of the current study was to (1) characterize the mandibular bone formation rate (BFR/BS), bone mass, indentation modulus (IM), and hardness of C3H and B6 mice and (2) investigate the relationship of the mechanical properties in three skeletal sites: mandible, femur, and tibia. Specimens from 17-week-old female C3H and B6 (n = 15/group) mice were obtained. Mandibular bone mass was estimated from the lateral-view area (LVA) and transverse cross sections. BFR/BS was measured in the mandibular section distal to the third molar. In addition, bone blocks from the distal surface of the third molar and the femoral and tibial midshaft were obtained for mechanical testing. BFR/BS, cortical area, and LVA were greater (P < 0.001) in C3H mandibles. IM was approximately 2 GPa higher in the C3H mandible (P > 0.05), femur (P < 0.001), and tibia (P < 0.01). Mandibular IM was lower (P < 0.05) than the femoral and tibial IM within each inbred mouse. IM was not significant between C3H and B6 mandibles. However, the magnitude of the difference ( approximately 12%) in the mandible was similar to the difference in the appendicular skeleton. This mandibular bone phenotype is similar to that observed in the appendicular skeleton of these distinct inbred mice.

The surface anabolic activity was not different between the body and the alveolar process of the mandible. The surface activity was greater in the C3H mandible than in the maxilla. Although secondary osteonal bone remodeling existed in the C3H and B6 alveolar bone, this process was not a consistent finding.

This study suggests that there is no difference in managing postoperative pain and swelling with betamethasone versus betamethasone and ketorolac.