Oxadiazole ring system occupies a significant position among heterocyclic templates for medicinal compounds due to its wide spectrum of biological activities. This article entails an in-depth review of the ability of oxadiazole derivatives to induce apoptosis of cancer cells. FDA has approved a number of drugs for the treatment of different types of cancer. There is, however, a continuing need for the development of new anticancer agents due to increasing cases of drug resistance. Moreover, medicinalchemists are continuously struggling to invent selective cytotoxic agents with minimum side effects. This work reviews the significance of oxadiazole ring system and its potential to act as a template for novel anticancer agents.
Helicoverpa armigera is considered as widespread and cosmopolitan insect responsible for drastic decline in chickpea productivity across the world. Management of H. armigera is of prime importance to achieve sustainable chickpea yields. Its life cycle passes through egg, larvae, pupae and adult stages in about 4-5 weeks. 1 st to 3 rd instar larvae generally feed on leaves, twigs and flowers. In later stages larger larvae (4 th to 6 th instar caterpillars) shift to developing pods by making holes/bores and consume entire developing seeds. Pod borers can cause yield losses up to 90 percent depending upon the insect density and susceptibility of cultivars. Sustainable management of chickpea pod borer involves use of resistant cultivars, manipulation of sowing dates, maintaining low crop density, management of nutrition, use of trap crops (maize, sunflower, sorghum, safflower, pigeon pea, okra and tomato), installing animated bird perches and application of biological control measures (use of plant extracts, virus/bacteria based insecticides). In case of pod borer outbreaks, chemical insecticides remain as last option for farmers. However, management of chickpea pod borer through use of resistant cultivars, adopting recommended cultural practices and biological control measures have been found more effective, economical, sustainable and eco-friendly.
The experiment was carried out in the spring season of 2017 in the open fields of the College of Agricultural Engineering Sciences/University of Baghdad/Al-Jadriya camps in order to improve the growth and yield of potato plants resulting from the cultivation of true potato seeds of the hybrid BSS-295 by spraying with two organic nutrients. The experiment included two factors: First one was spraying with Megafol nutrient at concentrations 0, 1, 2 and 4 ml l-1 and the second was spraying with Algazone nutrient at concentrations 0, 1.5 and 3 ml l-1, the experiment was applied according to the complete randomized block design with three replications and the averages were compared according to the LSD test 5%. The results indicate that spraying Megafol at a concentration of 4 ml L-1 led to a significant increase in plant height (64.60 cm), and plant yield (214 g plant-1). Spraying Algazone at a concentration of 3 ml L-1 led to a significant increase in plant height (56.47 cm), number of total stems (7.07 stem plant-1), leaf area (0.822 m2 plant-1), number of tubers (9.56 tuber plant-1), and the yield of the plant (144.90 g of plant-1). The interaction between Megafol 4 ml L-1 with Algazone 3 ml L-1 gave the highest value of plant height, number of total branches, chlorophyll content of leaves, tuber weight and plant yield (67.17 cm, 9.15 stem, 374.90 mg 100 g-1, 18.77 g. tuber-1, 235.00 g.plant-1 Respectively).
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