Objective: The current study aims to determine total flavonoid content (TFC), total phenolic content (TPC), and total carotenoid content (TCC) of ethanolic extract of Purslane (Portulaca oleraceae L.). Material and Method: Herb of Purslane (Portulaca oleraceae L.) was extracted using ethanol. Determination of total flavonoid content (TFC), total phenolic content (TPC), and total carotenoid content (TCC) The method used spectrophotometer UV-VIS by the used standard curve to compare the total content by linear regression calculation. Result: The results of this study demonstrated the TPC, TFC, and TCC value was 2.00 mg HE/g DW, 0.53 mg EQ/g DW, 128 mg GAE/g DW, respectively. For anti-obesity, a 200 mg/kg BW sample group had the greatest percentage decrease compared to the other groups (21.868%). Conclusion: This study showed that Purslane is a good source of flavonoids, phenolic, and carotenoids. Meanwhile, the ethanol extract of this plant has prospect potential as anti-obesity.
Inflammation is body response to prevent infection or tissue damage caused toxin or microbe in the body. Inflammation is usually treated with drugs known as NSAIDs (non-steroidal anti-inflammation drugs). However, the treatment with NSAID drugs often has side effects such as stomach irritation. Lately, the researchers are very aggressively finding an alternative therapy in treating inflammation by using medical herbal. The purpose of this study was to determine an anti-inflammatory activity of jackfruit leaves (Artocarpus heterophyllus Lam.) in male rats. Animal models were made by induced lambda carrageenan by intraplantar. This study consist of 4 groups: negative control (Na-CMC), methylprednisolone dose 45 mg / kg, methanol extract of jackfruit leaves (EMDN) doses 75 mg / kg and 150 mg / kg. Parameters were tested by measuring the volume of feet for 8 hours after induction of carrageenan using the plethysmometer. The results showed that the methanol extract of jackfruit leaves (EMDN) dose of 150 mg/kgbw has anti-inflammatory effects by inhibiting oedema in rats with 55.4% better than methanol extract of jackfruit leaves (EMDN) dose of 75 mg/kgbw with 23.9%.
Nephrotoxicity is a disorder of the kidneys that occurs when exposed to drugs or toxins. Pandan wangi leaves have antioxidant activity expected to give antinephrotoxicity effect. This aim of study is to determine the antinephrotoxicity effect of the ethanol extract of pandan wangi leaves (Pandanus amaryllifolius Roxb.) based on the decline of rat creatinine level induced by gentamicin. Eighteen male Wistar rats were divided into 6 groups. That is naive, negative control by Na-CMC 1%, positive control by the suspension of keto acids, and treatment group with ethanol extract of pandan wangi leaves at 125 mg/kgBW, 250 mg/kgBW and 500 mg/kgBW. Nephrotoxicity condition was induced by Gentamicin 80 mg/kgBW (ip) for seven days. The blood samples were taken and measured the serum creatinine levels on days 0, 8 th and 22 th by Human Analyzer. The results study showed that ethanol extract of pandan wangi leaves at 250 mg/kgBW and 500 mg/kgBW have the effect as antinephrotoxicity based on decreased creatinine levels.
Nephrotoxicity is a disorder of the kidneys that occurs when exposed to drugs or toxins. Pandan wangi leaves have antioxidant activity expected to give antinephrotoxicity effect. This aim of study is to determine the antinephrotoxicity effect of the ethanol extract of pandan wangi leaves (Pandanus amaryllifolius Roxb.) based on the decline of rat creatinine level induced by gentamicin. Eighteen male Wistar rats were divided into 6 groups. That is naive, negative control by Na-CMC 1%, positive control by the suspension of keto acids, and treatment group with ethanol extract of pandan wangi leaves at 125 mg/kgBW, 250 mg/kgBW and 500 mg/kgBW. Nephrotoxicity condition was induced by Gentamicin 80 mg/kgBW (ip) for seven days. The blood samples were taken and measured the serum creatinine levels on days 0, 8 th and 22 th by Human Analyzer. The results study showed that ethanol extract of pandan wangi leaves at 250 mg/kgBW and 500 mg/kgBW have the effect as antinephrotoxicity based on decreased creatinine levels.
Inflammation is body response to prevent infection or tissue damage caused toxin or microbe in the body. Inflammation is usually treated with drugs known as NSAIDs (non-steroidal anti-inflammation drugs). However, the treatment with NSAID drugs often has side effects such as stomach irritation. Lately, the researchers are very aggressively finding an alternative therapy in treating inflammation by using medical herbal. The purpose of this study was to determine an anti-inflammatory activity of jackfruit leaves (Artocarpus heterophyllus Lam.) in male rats. Animal models were made by induced lambda carrageenan by intraplantar. This study consist of 4 groups: negative control (Na-CMC), methylprednisolone dose 45 mg / kg, methanol extract of jackfruit leaves (EMDN) doses 75 mg / kg and 150 mg / kg. Parameters were tested by measuring the volume of feet for 8 hours after induction of carrageenan using the plethysmometer. The results showed that the methanol extract of jackfruit leaves (EMDN) dose of 150 mg/kgbw has anti-inflammatory effects by inhibiting oedema in rats with 55.4% better than methanol extract of jackfruit leaves (EMDN) dose of 75 mg/kgbw with 23.9%.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.