A series of azo-azomethine compounds (Sb1- Sb5) have been synthesized with magnificent yield by condensation reaction of 4-((3-formyl-4-hydroxy-5-methoxyphenyl)diazenyl) enzenesulfonamide and aniline derivatives. The new azo compound was prepared from sulfanilamide by converting it to diazonium salt followed by coupling reaction with 2-hydroxy-3-methoxybenzaldehyde in alkaline medium. The structures of synthesized azo and azo-azomethine compounds have been established based on their spectral data (FT-IR,1HNMR,13CNMR)and elemental analysis (C,H,N).The purity of compound and evaluation of Rf value were determined by TLC. The antimicrobial activity of azo-azomethine compounds have been tested in vitro against bacteria (Staphylococcus aureus, Escherichia coli and Klepsilia pneumonia) and fungi (Candida glabrata, Candida albicane and Aspergillus niger) by agar diffusion method, to assess their inhibiting potential. Also the antioxidant efficiency of azo-azomethine compounds have been calculated.
In this study, one species of algae, belongated to cyanophyta : Hapalosiphon aureus west and west 1897 were isolated, identified and purified. The extracts of algal isolates were testing to clarify their ability on growth inhibition on each of gram +ve and gram –ve bacteria E.coli & S. aureus, filamentous fungi A. fumigatus, and yeasts C.albican. The extracted alkaloid of species H.aureus showed higher inhibition activity. In our literature survey, the alkaloid compound analog N- methylcytisine was isolated for the first time from the H.aureus . This compound was characterized using Thin Layer Chromatography (TLC), Ultra Violet Spectrum (UV), Infrared Spectrum (IR), Proton Nuclear Magnetic Resonance Spectroscopy (1HNMR), Melting Point and Solubility in organic and inorganic solvents. The biological activity of this alkaloid was determined using the Minimal Inhibitory Concentration (MIC) against six bacterial isolates. The results showed inhibition in 33.3% growth of bacteria on 150 μg/ml concentration level, while the MIC against six fungi isolates showed inhibition of growth 33.3% at 50 μg/ml compared to standard antibiotic. The median lethal dose (LD50) showed no toxicity, no cytotoxicity and no effect on human red blood cells for 18 hours.
The increasing interdependence between the countries of the world has led to an increase in the risks faced by societies in general. The COVID-19 pandemic, for example, has transcended national borders, affecting people regardless of nationality, level of education, income or gender. As for its consequences, it has affected the most vulnerable groups. In this study, we have considered the significance of low plasma homocysteine or hypohomocysteinemia and some parameters of the syndrome associated with COVID-19. Just as an increase in the level of homocysteine in plasma has a negative effect on the heart and blood vessels, its decrease may put the health of those who suffer from it at risk. Homocysteine is known to be the natural mediator of the conversion of methionine to cysteine; hence, the danger, as the latter is necessary for the production of glutathione, taurine and sulphate. In this study, homocysteine and some indicators of COVID-19 syndrome were examined using ELISA kit and other methods. The homocysteine level in the serum of people who recovered from COVID-19 was found to be lower than in normal and healthy people. Thus, it indicates that people who have been cured may suffer from hypohomocystinemia. We also study some parameters, such as ALP, GOT, GPT, Glucose level and HDL, cholesterol. The results showed a significant decrease in the level of GOT enzyme and HDL level.
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