New azo-azomethine derivative of sulfanilamide: Synthesis, Characterization, Spectroscopic, Antimicrobial and Antioxidant activity study

Abstract

A series of azo-azomethine compounds (Sb1- Sb5) have been synthesized with magnificent yield by condensation reaction of 4-((3-formyl-4-hydroxy-5-methoxyphenyl)diazenyl) enzenesulfonamide and aniline derivatives. The new azo compound was prepared from sulfanilamide by converting it to diazonium salt followed by coupling reaction with 2-hydroxy-3-methoxybenzaldehyde in alkaline medium. The structures of synthesized azo and azo-azomethine compounds have been established based on their spectral data (FT-IR,1HNMR,13CNMR)and elemental analysis (C,H,N).The purity of compound and evaluation of Rf value were determined by TLC. The antimicrobial activity of azo-azomethine compounds have been tested in vitro against bacteria (Staphylococcus aureus, Escherichia coli and Klepsilia pneumonia) and fungi (Candida glabrata, Candida albicane and Aspergillus niger) by agar diffusion method, to assess their inhibiting potential. Also the antioxidant efficiency of azo-azomethine compounds have been calculated.

Synthesis, Characterization, and Antioxidant, Antimicrobial and Toxic Properties of Novel Δ2 -1,3,4-thiadiazoline and Δ2 -1,3,4-selenadiazoline Derivatives

“…29 The β-carotene bleaching method is based on the loss of the yellow color of β-carotene because of its reaction with radicals formed by linoleic acid oxidation in an emulsion and according to previous methods. 30,31 A solution of β-carotene was prepared by dissolving 0.01-gm of β-carotene in 50 mL of chloroform, 1-mL of this solution was then pipetted into round-bottom rotary flask containing (0.02 mL) of linoleic acid and (0.2 mL) of Tween-20. After removing the chloroform by vacuum evaporation using a rotary evaporator at room temperature, 50 ml of distilled water were added to the flask with manual shaking as first stage.…”

Synthesis, Spectroscopic characterization and bactericidal valuation of some metal (II) complexes with new Tridentate Heterocyclic Azo Ligand Type (NNO) Donor

“…The infrared spectral data of azo ligand and its complexes have illustrated in Figures (12)(13)(14)(15) and Table (3). The IR spectra for complexes have compared with those of the free ligand with the intention of determining the coordination sites that can be included in chelation.…”

“…[13,14]. In recent years, a significant number of tridentate azo compounds have a heteroaryl ring systems and have been developed for improving the colouring features and to accomplish more selectivity and specificity in chemical analysis [15]. Metal dye complexes have a highly significant role in dye-stuff technology [16] and find uses in countless fields, particularly in analytical chemistry [17].…”

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“…Sulfonamides have been utilized to treat cancer as a chemotherapeutic agent and a number of diseases greater than antifungals, non-peptide vasopressin receptor antagonists, antihypertensive agents, anti-inflammatory, antibacterial, translation initiation inhibitors, antineoplastic agents, diuretics, thyroid inhibitors, antitumor, carbonic anhydrase inhibitors, and glucocorticoid inhibitors are among the 30 sulfonamide derivatives in clinical use [18][19][20][21]. Blood, potassium channels, carboxypeptidase inhibitors, hepatitis viral (HCV) polymerase inhibitors, protease inhibitors, and the HIV-1 integrity [22][23][24][25]. In this work, we attempted to use a diazotization coupling reaction between sulfamethoxazole (a sulfur-containing organic compound) and (8-hydroxyquinoline) to form [4-((8-hydroxyquinolin-7-yl)-N(4-methylisoxazol-3yl)benzene sulfonamide(HL)], which is classified as an azo-compound that coordinates with each of Ni(II), Pt(IV), Pd(II), and Rh(III).…”