To improve the management of psoriasis, we have started from the hypothesis that normalization of vitamin D serum reduces the severity of psoriasis and positively influences the diagnostic criteria of metabolic syndrome. Experimental part. The objective of the prospective study was to evaluate the impact of oral vitamin D on psoriazis and metabolic syndrome in a group of 184 patients diagnosed with psoriazis and metabolic syndrome, between 2010-2017. In all patients included in the study, we evaluated family history, personal medical history, the living and working conditions, the history of psoriatic disease (control group only), clinical data (waist circumference), height (cm), body mass index, blood pressure (mmHg)) and laboratory examinations. Regarding the severity of psoriasis, in all 141 patients treated with vitamin D, a significant improvement was seen after 12 months of treatment. We bring a new approach to the treatment of psoriasis with vitamin D.
Objectives: To investigate paraoxonase-1 (PON 1 ) lactonase activity, myeloperoxidase (MPO) activity (as a marker of inflammation) and antioxidant status in plasma of patients with type 1 diabetes mellitus. Methods: Whole blood and plasma samples were collected from patients with diabetes and healthy control subjects. PON 1 lactonase and MPO activities and total antioxidant capacity (TEAC) were determined in plasma. Glycosylated haemoglobin (HbA1c) was quantified in whole blood. Results: Plasma PON 1 lactonase and MPO activities were significantly higher and TEAC was significantly lower in patients with diabetes (n ¼ 18) compared with healthy control subjects (n ¼ 20). There were significant positive correlations between PON 1 lactonase activity and MPO activity and HbA1c level, and plasma MPO and HbA1c. There were significant negative correlations between PON 1 lactonase activity and TEAC, and MPO activity and TEAC. Conclusions: Increased lactonase activity may inefficiently compensate for the high level of chronic inflammation and low antioxidant capacity in the plasma of patients with type 1 diabetes mellitus.
Depresia reprezintă o afecţiune comună, mai ales în rândul persoanelor care sufer ă de boli cronice. O parte dintre pacienţii diagnosticaţi cu depresie nu realizează că suferă de această afecţiune şi, prin urmare, nu apelează la ajutor profesional. Medicul de familie este primul care intră în contact cu aceşti pacienţi şi tot el este cel care le monitorizează evoluţia. Atitudinea medicului de familie în ceea ce priveşte depresia poate influenţa atât atitudinea pacientului faţă de depresie, cât şi atitudinea acestuia faţă de tratament.
Importanţa supradIagnostIcărII în medIcIna de famIlIe. cum mInImalIzăm rIscurIle? The importance of overdiagnosis in family medicine. How do we minimize the risks? asist. univ. ana maria alexandra stănescu 1 , Şef lucr. dr. Ioana Veronica grăjdeanu 1 , asist. univ. dr. Bogdan Şerban 1 , conf. dr. ovidiu gabriel Bratu 1,2 , conf. Habil. dr. camelia cristina diaconu ¹,3
Although a common condition, acne is a complex condition that involves chronic inflammation and hyperkeratosis of the hair follicles, increased sebum secretion, and colonization of Propionibacterium acnes. Metformin has been found to play a role in acne, particularly hormonal acne. Our goal is to review the relevant studies and their results following metformin administration in patients with acne.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.