Does metformin play a role in the treatment of acne?

Stănescu, Ana Maria Alexandra; Grăjdeanu, Ioana Veronica; MIRICESCU, Daniela; Șerban, Bogdan; Lăzărescu, Horia; Brezan, Florin; Kozma, Andrei

doi:10.31688/abmu.2019.54.4.20

Cited by 2 publications

(6 citation statements)

References 13 publications

(17 reference statements)

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“…The global score is the result of the summation of individual scores. Depending on the obtained result, the GAGS defines acne as mild (1)(2)(3)(4)(5)(6)(7)(8)(9)(10)(11)(12)(13)(14)(15)(16)(17)(18), moderate (19)(20)(21)(22)(23)(24)(25)(26)(27)(28)(29)(30), severe (31)(32)(33)(34)(35)(36)(37)(38), and very severe (>39) [67].…”

Section: Gags Assessmentmentioning

confidence: 99%

Metformin Therapy for Acne Vulgaris: A Meta-Analysis

Szefler,

Szybiak-Skora,

Sadowska-Przytocka

et al. 2024

Pharmaceuticals

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Acne vulgaris is a common disease, which occurs in adolescents as well as adults and has a significant influence on the patient’s quality of life (QoL) in every aspect. Due to resistance to standard therapies, it has become necessary to prospect for new treatment strategies. It is important to highlight that the diagnosis and treatment of the underlying cause of acne such as metabolic and hormonal disorders may significantly improve the effectiveness of acne treatment. The correlation between Insulin Resistance (IR) and acne has been proven. Both disorders share many common occurrence factors and activation pathways. Metformin, an antihyperglycemic agent, seems to be a possible therapy option, not only because of its insulin sensitizing ability but also via plenty of additional effects of this medicine. While the efficiency of metformin therapy in patients with acne and Polycystic Ovary Syndrome (PCOS) is well explored, it is still necessary to evaluate it in patients without any endocrinopathies. This meta-analysis aimed to estimate the effectiveness of oral metformin as a monotherapy in acne patients without PCOS or other endocrinopathies. Study selection was performed with included criteria such as no PCOS and other endocrinopathies diagnosed, oral administration of metformin, and metformin in monotherapy. Selected studies contained comparisons in the Global Acne Grading System (GAGS) before and after metformin therapy. Statistical analysis detected significant improvement in skin condition after treatment with metformin.

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Section: Gags Assessmentmentioning

confidence: 99%

Metformin Therapy for Acne Vulgaris: A Meta-Analysis

Szefler,

Szybiak-Skora,

Sadowska-Przytocka

et al. 2024

Pharmaceuticals

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“…IGF-1 may stimulate some comedogenic factors, such as androgens, growth hormone and glucocorticosteroids. Moreover, it increases lipid peroxidation in sebocytes, which results in increased sebum secretion [5][6][7].…”

Section: Trądzik Pospolitymentioning

confidence: 99%

“…Taking into account the above data, metformin as a drug that reduces IGF-1 levels, hyperinsulinemia and insulin resistance may be useful in the treatment of acne vulgaris [5].…”

Section: Trądzik Pospolitymentioning

confidence: 99%

“…Te dwa czynniki bezpośrednio wpływają na proliferację i apoptozę keratynocytów. IGF-1 może stymulować niektóre czynniki komedogenne, takie jak androgeny, hormon wzrostu i glikokortykosteroidy, ponadto zwiększa peroksydację lipidów w sebocytach, co skutkuje większym wydzielaniem łoju [5][6][7].…”

Section: Hidradenitis Suppurativaunclassified

“…Ze względu na powyższe dane metformina jako lek zmniejszający stężenie IGF-1, hiperinsulinemię oraz insulinooporność może być przydatna w leczeniu trądziku pospolitego [5].…”

Section: Hidradenitis Suppurativaunclassified

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Metformin in skin diseases

Kadylak¹,

Polak²,

Wojciechowska³

et al. 2021

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Metformin is the most widely used oral antidiabetic drug in the world. It is the first-line drug in type 2 diabetes, where its inhibiting effect on hepatic glucose production, increasing muscle and adipose tissue insulin sensitivity and reduction of glucose absorption in the gut are used. Many benefits to the skin condition have been reported from using metformin in dermatological diseases such as acne vulgaris, hidradenitis suppurativa, hirsutism as well as reducing the risk of certain skin malignancies and the occurrence of psoriasis. Some adverse effects of metformin have also been reported: rash, skin allergic reactions, drug reaction with eosinophilia and systemic symptoms (DRESS syndrome), bullous pemphigoid, leukocytoclastic vasculitis, nail discoloration with subungual hyperkeratosis. The article is a review of currently available literature on the influence of metformin on the course of various skin diseases and its adverse effects.streszczenie Metformina jest najczęściej stosowanym na świecie doustnym lekiem przeciwcukrzycowym. Stanowi lek pierwszego wyboru w terapii cukrzycy typu 2, gdzie wykorzystywany jest jej efekt hamowania wątrobowej produkcji glukozy, zwiększania insulinowrażliwości mięśni i tkanki tłuszczowej oraz zmniejszania wchłaniania glukozy w jelitach. W piśmiennictwie istnieje wiele doniesień o korzystnym wpływie metforminy na stan skóry w chorobach dermatologicznych, takich jak trądzik zwyczajny, hidradenitis suppurativa, hirsutyzm, a także o redukowaniu ryzyka rozwoju niektórych nowotworów złośliwych skóry oraz wystąpienia łuszczycy. Donoszono także o niepożądanych działaniach metforminy: występowaniu osutek, skórnych reakcji alergicznych, reakcji polekowej z towarzyszącą eozynofilią i objawami ogólnymi (drug rash with eosinophilia and systemic syndrome -DRESS), pemfigoidu pęcherzowego, leukocytoklastycznego zapalenia naczyń, przebarwień paznokci z podpaznokciową hiperkeratozą. Artykuł stanowi przegląd dostępnej literatury dotyczącej wpływu metforminy na przebieg różnych chorób skóry oraz jej działań niepożądanych.

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Does metformin play a role in the treatment of acne?

Cited by 2 publications

References 13 publications

Metformin Therapy for Acne Vulgaris: A Meta-Analysis

Metformin Therapy for Acne Vulgaris: A Meta-Analysis

Metformin in skin diseases

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