BackgroundAnnually 8500 total knee arthroplasty (TKA) are performed in Denmark. About 80% of this population is overweight or obese. The present material is part of a longitudinal randomized study (ClinicalTrial.gov: NCT01469403).ObjectivesTo investigate whether it is feasible and safe to implement an intensive weight loss program in order to reduce preoperative body weight of obese patients before TKA surgery. The primary aim of the Weight Loss Intervention before Total Knee Arthroplasty (WITKA) study is to investigate whether weight loss interventions before total knee arthroplasty (TKA) will improve QoL and physical function 1 year after surgery.MethodsWe conducted a single-blind, randomized study. Eligible patients were scheduled for TKA due to osteoarthritis (OA) of the knee and obesity (BMI ≥30kg/m2). Participants were randomized to either a control group that followed the standard care or a weight loss group that followed a low-energy diet (810 kcal/day) 8 weeks before surgery. Outcomes were assessed before intervention for the weight loss group, and within 1 week preoperatively for both the weight loss group and the control group. The primary outcome in the WITKA study was the Short-Form 36 (SF-36). Secondary outcomes were Knee injury and Osteoarthritis Outcome Score (KOOS), 6 Minutes' Walk Test, and body composition.ResultsIncluded were 77 patients (weight loss group n=38; control group n=39), 71% were females, the mean age was 65 years (range 46-85), and the average BMI was 31. The average weight loss after 8 weeks was 10.7 kg (10% of body weight). According to dual energy X-ray absorptiometry (DXA), the weight loss consisted of a 6.7 kg reduction in fat mass, a 3.0 kg reduction in lean body mass, and lean body mass increased by 2.3%. In addition, cholesterol decreased and systolic blood pressure decreased by 12 mm/Hg. The intensive diets had few and mild adverse effects. Serious cardiac complications were found in two cases in the intervention group and in one case in the control group. All three patients later underwent TKA without complications. No perioperative complications were recorded in any group.ConclusionsOur results suggest that it is feasible and safe to implement an intensive weight loss program shortly before TKA.ReferencesMessier SP, Gutekunst DJ, Davis C, DeVita P. Weight loss reduces knee-joint loads in overweight and obese older adults with knee osteoarthritis. Arthritis Rheum. 2005;52(7):2026–32Bliddal H, Leeds AR, Stigsgaard L, Astrup A, Christensen R. Weight loss as treatment for knee osteoarthritis symptoms in obese patients: 1-year results from a randomised controlled trial.Liljensøe A, Lauersen JO, Søballe K, Mechlenburg I. Overweight preoperatively impairs clinical outcome after knee arthroplasty: a cohort study of 197 patients 3–5 years after surgery. Acta Orthop. 2013;84(4):392–7.AcknowledgementsThe Danish Rheumatism Association; Linak A/S; Fabrikant Mads Clausens foundation Danfoss; Johs. M. Klein and wife foundation; Knud and Edith Eriksens foundation; Peter Ryholts foundati...
Introduction Patients undergoing major cardiothoracic or abdominal surgery are at increased risk of developing post‐operative pulmonary complications (PPC), but respiratory physiotherapy can prevent PPC. We have previously developed the PPC Risk Prediction Score to allocate physiotherapists' resources and stratify patients into three risk groups. In this study, we performed a temporal external validation of the PPC Risk Prediction Score. Such validation is rare and adds to the originality of this study. Methods A cohort of 360 patients, admitted to undergo elective cardiothoracic or abdominal surgery, were included. Performance and clinical usefulness of the PPC Risk Prediction Score were estimated through discrimination, calibration and clinical usefulness, and the score was updated. Results The score showed c‐statistics of 0.62. Related to clinical usefulness, a cut point at 8 gave a sensitivity of 0.49 and a specificity of 0.70, whereas a cut point at 12 gave a sensitivity of 0.13 and a specificity of 0.95. Two predictors included in the development sample score, thoraco‐abdominal incision odds ratio (OR) 2.74 (1.12;6.71) and sternotomy OR 2.09 (1.18;3.72), were statistically significantly associated to PPC in the validation sample. Conclusions The score was not able to discriminate between patients with and without PPC; neither was the updated score, but the study identified clinically relevant risk factors for developing PPC.
Background and purpose: Dual mobility (DM) articulation total hip arthroplasty (THA) is used increasingly to reduce dislocation risk. We investigated cup fixation, polyethylene (PE) wear, serum chromium and cobalt ions, and their correlation to physical activity in patients with DM cups at 6-year follow-up.Patients and methods: In a patient-blinded RCT, 60 patients with hip osteoarthritis at a median age of 74 years (70–82) were randomly allocated to cemented (n = 30) or cementless hydroxyapatite-coated (n = 30) fixation of Avantage DM THA with a highly-crosslinked vitamin-E PE liner. Cup migration and PE wear were measured with radiostereometric analysis (RSA), chromium and cobalt ions were measured in serum, and physical activity was measured with accelerometers.Results: At 6-year follow-up, proximal cup migration was similar: 0.14 mm (95% CI 0.01–0.28) for cemented cups and 0.21 mm (0.02–0.39) for cementless cups. The PE wear rate from 1- to 6-year follow-up was also similar: 0.06 mm/year (0.04–0.09) for cemented cups and 0.07 mm/year (0.04–0.11) for cementless cups. Serum metal ion levels were undetectable or very low. Physical activity was mainly low intensity and did not correlate to PE wear rate or cup migration.Conclusion: Cemented and cementless DM cups with highly crosslinked vitamin-E infused liners have similar cup migration and PE wear when used for primary THA surgery.
(1) Background: Metal-on-metal (MoM) total hip arthroplasty (THA) and hip resurfacing arthroplasty (HRA) was presumed to provide superior functional outcomes compared to metal-on-polyethylene (MoP) THA. (2) Methods: We compared muscle mass, power, step test asymmetry, and patient-reported outcomes between MoM THA/HRA and MoP THA. A total of 51 MoM THA/HRAs and 23 MoP THAs participated in the cross-sectional study at a mean of 6.5 (2.4–12.5) years postoperatively. Muscle mass was measured by Dual energy X-ray Absorption (DXA) scans and muscle power in a Leg Extensor Power Rig. Step test asymmetry was obtained with an Inertial Measurement Unit (IMU). The patients completed the Harris Hip Score (HHS) and the Copenhagen Hip and Groin Outcome Score (HAGOS). (3) Results: The MoM THA/HRA group had a greater inter-limb difference in hip muscle mass compared to the MoP THA group (p = 0.02). Other inter-limb differences in muscle mass and power were similar (p > 0.05). Muscle mass of the thigh and calf area and muscle power in both legs were higher in MoM THA/HRA compared to MoP THA (p < 0.009). Step test time asymmetry when ascending was lower in MoM THA/HRA compared to MoP THA (p = 0.03). HHS and HAGOS scores were similar between groups (p > 0.05). (4) Conclusion: Overall, we could not verify the hypothesis that MoM THA/HRA contributes to superior functional outcomes compared to MoP THA.
BACKGROUND Physical activity (PA) is emerging as an outcome measure. Accelerometers have become an important tool in monitoring physical behavior and newer analytical approaches of recognition methods increase the degree of details. OBJECTIVE The purpose of this study was to develop and validate an algorithm for classifying several daily physical behaviors using a single thigh-mounted accelerometer and a supervised machine learning scheme. METHODS We collected training data for adding further behavior classes to an existing algorithm. Combining data, we were potentially able to classify 11 behaviors, using a Random Forest learning scheme. We validated the algorithm through a simulated free-living procedure using chest-mounted cameras for establishing the ground truth. Furthermore, we adjusted our algorithm and compared the performance with a validated algorithm. RESULTS In the simulated free-living validation, the performance of the algorithm decreased to 64% as a weighted average for the 11 classes (F-measure). After reducing to 5 classes corresponding with the validated algorithm, the result revealed high performance in comparison with both the ground truth and the validated algorithm. CONCLUSIONS We developed an algorithm to classify 11 physical behaviors. We obtained high classification levels within specific behaviors, while others yielded lower classification potential.
Aim To examine whether patients' body mass index is associated with missed hip fracture care consistent with national guideline‐recommended care. Design A nationwide, population‐based cohort study using prospectively collected data from the Danish Multidisciplinary Hip Fracture Registry. Methods The study population consisted of 39,835 patients ≥65 years admitted with a hip fracture and discharged between 1st of January 2012 and 29th of November 2017. National guideline‐recommended care consists of preoperative optimization, early surgery, mobilization within 24 h, basic mobility assessment, nutrition screening, post‐discharge rehabilitation program, and osteoporotic and fall prophylaxis. We used binomial regression to estimate the relative risk for the fulfilment of the individual measures with 95% confidence interval. Multiple imputation method was applied to handle missing values of body mass index. Results The overall fulfilment of the individual measures ranged from 43% for pre‐operative optimization to 95% for receiving a post‐discharge rehabilitation program. The obese patients had a lower fulfilment of surgery within 36 h compared to patients with normal weight. No differences in fulfilment of the other measures were found. However, patients with missing data on body mass index had the highest risk of missed care. In conclusion, patients with missing BMI values had the highest risk of missed care. The obese patients had a slightly higher risk of long waiting times for surgery than normal‐weighted patients. No Patient or Public Contribution This study was done based on population‐based data from medical registries and data was analysed by the authors only.
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