Sn Mössbauer, IR and mass spectral studies in combination with melting points and elemental analyses. The compounds have been screened for in vitro anti-leishmanial activity against promastigotes of Leishmania major and the results offer potent activities which are better than the standard drug, pentamidine, for one compound.

A series of trimethyltin(IV) carboxylates (1-7) , having general formula [(CH 3 ) 3 SnOOCR], where R = 3-CF 3 C 6 H 4 - (1) , 3,4-(OCH 2 CH 3 ) 2 C 6 H 3 - (2) , 3-FC 6 H 4 - (3) , 4-ClC 6 H 5 - (4) , 2,4-(OCH 3 ) 2 C 6 H 3 - (5) , 4-NO 2 C 6 H 4 - (6) , 5-CH 3 C 4 H 2 N 2 - (7) have been synthesized and are characterized by using analytical techniques like, FT-IR, 1 H, 13 C and 119 Sn NMR spectroscopy in addition to elemental analyses. To validate the structural motif, one of the complex (2) was also analyzed by single crystal XRD technique. The single crystal X-ray diffraction analysis revealed that the molecular species exist in one dimensional polymeric chain, wherein five coordinated tin is attached to two oxygens of the carboxyl and three carbon atoms of CH 3 groups, whereas the bond angles for C-Sn-C (117.20–121.65°), C-Sn-O (87.87–98.60°) and O-Sn-O (173.75°) lie in the predictable range of distorted trigonal bipyramidal geometry. All the synthesized complexes were also subjected to preliminary screening for various biocidal applications such as antimicrobial, anti-diabetic, protein kinase inhibition and brine shrimp lethality test to check their efficacy. The compound 6 exhibits very good antibacterial activity having MIC value 6.25 μg/mL against K. pneumoniae , whereas antidiabetic and protein kinase inhibition data revealed that 1 and 2 may serve as good to moderately effective inhibitors, respectively.

A series of new thiourea based carboxylic acids (Ia-Ie) were synthesized and characterized by elemental analysis, FTIR and NMR (1 H and 13C) spectroscopy. They were preliminary bioassayed for their antibacterial, anifungal and urease inhibition activities. Molecular docking simulations were carried out to determine the probable binding mode of the synthesized compounds. The bioassay results showed that some of titled compounds exhibited encouraging results.