Six new organotin(IV) derivatives [Me 3 SnL 1 ] (1), [Bu 3 SnL 1 ] (2), [Ph 3 SnL 1 ] (3), [Me 3 SnL 2 ] (4), [Bu 3 SnL 2 ] (5) and [Ph 3 SnL 2 ] (6) (where HL 1 = = 9-fluoro-6,7-dihydro-5-methyl-1-oxo-1H,5H-pyrido[3,2,1-ij]quinoline-2-carboxylic acid (flumequine) and HL 2 = 2-[2-[4-[(4-chlorophenyl)phenylmethyl]-1-piperazinyl]ethoxy] acetic acid (cetirizine)) were synthesized and characterized by elemental analysis, FT-IR spectroscopy, multinuclear 1 H-, 13 C-and 119 Sn-NMR, mass spectrometry and thermal analysis techniques. The obtained data reveal trigonal-bipyramidal geometry in case of complexes 1, 2, 4 and 5, and tetrahedral geometry for complexes 3 and 6 around the tin atom, whereas in complexes 3 and 6 the carboxylate ligand act as monodentate ligand through one of its oxygen atoms while it acts as bidentate ligand through two oxygen atoms for complexes 1, 2, 4 and 5. The antibacterial and antifungal efficacies of complexes 1-6 were assessed and the majority of the compounds showed good activities. The present research showed that the trimethyltin(IV) derivatives were particularly more effective than tributyltin(IV) and triphenyltin(IV) derivatives against all the bacterial and fungal strains. Antioxidant and DNA binding studies were also performed and promising results were obtained.
The title compound, [Ni(C12H8N2)3]2[Ag(CN)2]3(NO3)·4.2H2O, crystallizes with two independent [Ni(phen)3]2+ cations (phen is 1,10-phenanthroline; both Ni atoms have threefold symmetry and N6 donor sets), three near-linear [Ag(CN)2]− anions, one nitrate anion (N site symmetry 3) and 4.2 water molecules of crystallization, some of which are disordered. The [Ag(CN)2]− anions are situated within cavities created by the phenanthroline ligands of adjacent [Ni(phen)3]2+ cations. Some short C—H⋯O and C—H⋯N interactions may help to establish the packing.
A series of new thiourea based carboxylic acids (Ia-Ie) were synthesized and characterized by elemental analysis, FTIR and NMR (1 H and 13C) spectroscopy. They were preliminary bioassayed for their antibacterial, anifungal and urease inhibition activities. Molecular docking simulations were carried out to determine the probable binding mode of the synthesized compounds. The bioassay results showed that some of titled compounds exhibited encouraging results.
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