In vitro anti-leishmanial activities of germatranyl and Silicon incorporated diorganotin derivatives: Synthesis and spectroscopic properties

Abstract

Sn Mössbauer, IR and mass spectral studies in combination with melting points and elemental analyses. The compounds have been screened for in vitro anti-leishmanial activity against promastigotes of Leishmania major and the results offer potent activities which are better than the standard drug, pentamidine, for one compound.

Synthesis and leishmanicidal activity of 2,3,4-substituted-5-imidazolones

“…In our ongoing research on leishmaniasis [17][18][19][20] , we synthesized 29 imidazolones, 1-29, by treating different oxazolones with varyingly substituted aromatic amines. In a typical reaction, a mixture of differently substituted E-oxazolones [21][22][23] (1 mmol) and substituted aromatic amines (1.1 mmol) in anhydrous pyridine were irradiated by microwaves to afford compounds 1-29.…”