Medicinal properties of organotin compounds and their limitations caused by toxicity

A novel compound of triphenyltin(IV) with N-tert-butoxycarbonyl-l-ornithine causes cancer cell death by inducing a p53-dependent activation of the mitochondrial pathway of apoptosis

“…Inorganica Chimica Acta 456 (2017) [1][2][3][4][5][6][7][8] Contents lists available at ScienceDirect Inorganica Chimica Acta j o u r n a l h o m e p a g e : w w w . e l s e v i e r .…”

“…Mitochondrial transmembrane potential (Dwm) was assayed by flow cytofluorometry, using the cationic lipophilic dye 3,30-dihexyloxacarbocyanine iodide [DiOC 6 Immunoreactions were also performed using b-actin antibody as loading controls.…”

“…Organotin(IV) derivatives have been prepared and tested in the past as possible anticancer agents [1][2][3][4][5][6] and many of them exhibited interesting activity in specific cancer models. Tin-based drugs represent an excellent alternative to platinum ones as antitumor agents, having the considerable advantage to display a lower toxicity.…”

“…Sn chemical shifts, in ppm, in CD 3 -OD and DMSO-d 6 solutions, are given in the experimental section. 13 C NMR resonances for the free ligand in solution could not be recorded due to its limited solubility.…”

Two new organotin(IV)-phosphoryl complexes: crystal structure and Hirshfeld surface analysis

“…Tin complexes are of great interest because of their unique properties in medicine, industrial applications and biological systems [1][2][3][4]. Among which the tin-phosphoryl complexes have received considerable attention due to the diverse structural features known for phosphoryl-donor ligands [5] and various applications such as anti-bacterial [6], anti-HIV [7] and anti-cancer [8] activities and also agricultural uses [9] and enzyme inhibitory [10] for phosphoryl compounds.…”