Objectives Diverticulitis is a common disease with high clinical burden. We evaluated the joint contribution of multiple lifestyle factors to risks of incident diverticulitis. We also estimated the proportion of diverticulitis preventable by lifestyle modifications. Methods We prospectively examined the association between lifestyle factors [red meat, dietary fiber intake, vigorous physical activity (activity with metabolic equivalent≥6), body mass index (BMI), and smoking] and risk of diverticulitis among participants in the Health Professionals Follow-Up Study. Results We documented 907 incident cases of diverticulitis during 757,791 person-years. High intake of red meat, low intake of dietary fiber, low vigorous physical activity, high BMI, and smoking were independently associated with increased risks of diverticulitis (all p<0.05). Low-risk lifestyle was defined as average red meat intake <51 grams/day, dietary fiber intake in the top 40% of the cohort (about 23 grams/day), vigorous physical activity in the highest 50% among participants with non-zero vigorous physical activity (roughly 2 hours of exercise weekly), normal BMI between 18.5–24.9 kg/m2, and never-smoker. There was an inverse linear relationship between number of low-risk lifestyle factors and diverticulitis incidence (p for trend<0.001). Compared to men with no low-risk lifestyle factors, the multivariable relative risks of diverticulitis were 0.71 [95% confidence interval (CI):0.59–0.87] for men with 1 low-risk lifestyle factor; 0.66 (95% CI:0.55–0.81) for 2 low-risk factors; 0.50 (95% CI:0.40–0.62) for 3 low-risk factors; 0.47 (95% CI:0.35–0.62) for 4 low-risk factors, and 0.27 (95% CI:0.15–0.48) for 5 low-risk factors. Adherence to a low-risk lifestyle could prevent 50% (95% CI:20–71%) of incident diverticulitis. Conclusions Adherence to a low-risk lifestyle is associated with reduced incidence of diverticulitis.

Red meat intake, particularly unprocessed red meat, was associated with an increased risk of diverticulitis. The findings provide practical dietary guidance for patients at risk of diverticulitis.

OPAT with β-lactam antibiotics is effective, but antibiotic switches for adverse events were more frequent with oxacillin use. Clinicians should be cognizant of the risk of readmissions and ADEs in OPAT patients, as the value of OPAT lies in reducing patient morbidity and readmissions by managing ADEs and preventing clinical failures.

During a 6-year follow-up period, we observed an association between obesity and risk of diverticulitis among women. Weight gain during adulthood was also associated with increased risk.

Background & Aims: Although low fiber intake has been considered a risk factor for diverticulitis, prospective evidence is limited and conflicting, with little known about variation in the protective effects according to food sources. We assessed the associations of intakes of fiber and major food sources of fiber including fruits and vegetables with risk of diverticulitis. Methods:We followed 50,019 women in the Nurses' Health Study (1990Study ( -2014 and 48,292 men in the Health Professionals Follow-up Study (1986-2014 who were free of diverticulitis, cancer, and inflammatory bowel disease at baseline. Incident diverticulitis was identified through selfreport with validity confirmed by review of medical records.Results: During a mean follow-up time of 22 years, we documented 4,343 incident cases of diverticulitis in women and 1,142 cases in men. Compared to participants in the lowest quintile, the multivariable HRs (95% CIs) of diverticulitis in the highest quintile of total fiber intake were 0.86 (0.78-0.95; P-trend=0.002) among women and 0.63 (0.51-0.79; P-trend<0.001) among men.Fiber from different food sources, except for vegetable fiber in women, was associated with a decreased risk of diverticulitis. Furthermore, total whole fruit intake was associated with reduced risk of diverticulitis in both cohorts with a multivariable HR for diverticulitis of 0.95 (0.92-0.98; P-trend<0.001) in women and 0.91 (0.86-0.96; P-trend<0.001) in men for every serving increase of total whole fruit intake per day.Conclusions: Higher intake of dietary fiber and fiber from different food sources are associated with a lower risk of diverticulitis. A greater intake of whole fruit is also associated with reduced risk.

Allergic contact dermatitis (ACD), a delayed hypersensitivity skin reaction to environmental allergens, has a prevalence that is similar in children and adults. However, diagnostic testing for ACD in pediatric populations accounts for less than one tenth of all patch tests. The relative infrequency of pediatric patch testing may be attributed to the difficulty in testing in this population, which includes a smaller surface area for patch test placement and maintaining cooperation during patch testing, especially in younger children. Diagnosis can be difficult in children because the appearance of ACD can mimic other common pediatric skin conditions, particularly atopic dermatitis and irritant contact dermatitis. Comprehensive history taking, guided by patient presentation, age group, and location of dermatitis, helps build clinical suspicion. Such clinical suspicion is one of the major reasons behind patch testing, with additional indications being recalcitrant dermatitis and dermatitis with atypical distribution. US pediatric data have shown the top allergens to be metals, fragrances, topical antibiotics, preservatives, and emollients. These trends are important to recognize to guide management and accurate diagnosis, because ACD tends to persist if the allergen is not identified and can affect patients' quality of life.

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