Association Between Inflammatory Diets, Circulating Markers of Inflammation, and Risk of Diverticulitis

Ma, Wenjie; Jovani, Manol; Nguyen, Long H.; Tabung, Fred K.; Song, Mingyang; Liu, Po Hong; Cao, Yin; Tam, Idy; Wu, Kana; Giovannucci, Edward; Strate, Lisa L.; Chan, Andrew T.

doi:10.1016/j.cgh.2019.11.011

Cited by 26 publications

(20 citation statements)

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“…Both scores comprise food combinations that maximally predict concentrations of circulating biomarkers: C-peptide for EDIH and inflammatory markers for EDIP ( 13 , 14 ). These biomarkers have been implicated in the pathogenesis of several chronic diseases, including type 2 diabetes ( 15 – 18 ). Both scores have been extensively applied in previous studies, with robust results on health outcomes ( 17 , 18 ).…”

Section: Introductionmentioning

confidence: 99%

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Insulinemic and Inflammatory Dietary Patterns Show Enhanced Predictive Potential for Type 2 Diabetes Risk in Postmenopausal Women

Shi

Aroke

et al. 2021

Diabetes Care

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OBJECTIVE The empirical dietary index for hyperinsulinemia (EDIH) and empirical dietary inflammatory pattern (EDIP) scores assess the insulinemic and inflammatory potentials of habitual dietary patterns, irrespective of the macronutrient content, and are based on plasma insulin response or inflammatory biomarkers, respectively. The glycemic index (GI) and glycemic load (GL) assess postprandial glycemic potential based on dietary carbohydrate content. We tested the hypothesis that dietary patterns promoting hyperinsulinemia, chronic inflammation, or hyperglycemia may influence type 2 diabetes risk. RESEARCH DESIGN AND METHODS We calculated dietary scores from baseline (1993–1998) food frequency questionnaires among 73,495 postmenopausal women in the Women’s Health Initiative, followed through March 2019. We used multivariable-adjusted Cox regression to estimate hazard ratios (HRs) and 95% CIs for type 2 diabetes risk. We also estimated multivariable-adjusted absolute risk of type 2 diabetes. RESULTS During a median 13.3 years of follow-up, 11,009 incident cases of type 2 diabetes were diagnosed. Participants consuming the most hyperinsulinemic or proinflammatory dietary patterns experienced greater risk of type 2 diabetes; HRs (95% CI) comparing highest to lowest dietary index quintiles were EDIH 1.49 (1.32–1.68; P trend < 0.0001) and EDIP 1.45 (1.29–1.63; P trend < 0.0001). The absolute excess incidence for the same comparison was 220 (EDIH) and 271 (EDIP) cases per 100,000 person-years. GI and GL were not associated with type 2 diabetes risk: GI 0.99 (0.88–1.12; P trend = 0.46) and GL 1.01 (0.89–1.16; P trend = 0.30). CONCLUSIONS Our findings in this diverse cohort of postmenopausal women suggest that lowering the insulinemic and inflammatory potentials of the diet may be more effective in preventing type 2 diabetes than focusing on glycemic foods.

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Section: Introductionmentioning

confidence: 99%

“…These biomarkers have been implicated in the pathogenesis of several chronic diseases, including type 2 diabetes ( 15 – 18 ). Both scores have been extensively applied in previous studies, with robust results on health outcomes ( 17 , 18 ).…”

Section: Introductionmentioning

confidence: 99%

Insulinemic and Inflammatory Dietary Patterns Show Enhanced Predictive Potential for Type 2 Diabetes Risk in Postmenopausal Women

Shi

Aroke

et al. 2021

Diabetes Care

Self Cite

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show abstract

“…I read with great interest the article by Ma et al 1 They conducted a prospective study to investigate the association between inflammation and the incidence of diverticulitis. Cox proportional hazards regression and conditional logistic regression models were applied to evaluate the risk of incident diverticulitis.…”

Section: Q1 Q2mentioning

confidence: 99%

Risk Factors of Diverticulitis With Special Reference to Inflammation

Kawada

2021

Clinical Gastroenterology and Hepatology

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“…Some studies have indicated that certain dietary components, ranging from low fiber to high fat, can cause dysbiosis by decreasing the abundance of beneficial bacteria and promoting the growth of harmful bacteria, leading to an increased intestinal permeability and therefore intestinal inflammation. 51, 52 The role of inflammatory potential of diet was recently investigated by Ma et al 53 They assessed the association between some potential inflammatory foods and chronic inflammation, represented by inflammatory and plasma levels of C -reactive protein and interleukin 6, and subsequent risk of diverticulitis. In a large prospective cohort of men, the authors found 1110 incident cases of acute diverticulitis over 992 589 person -years of follow -up.…”

Section: Fiber Intake and Occurrence Of Acute Diverticulitismentioning

confidence: 99%

“…Finally, the adjustment for body mass index or vigorous physical activity did not change the positive association between the inflammatory potential of diet and risk of acute diverticulitis. 53 White meat and fish Cao et al 50 have recently assessed the effect of white meat or fish consumption on the occurrence of acute diverticulitis. The risk of acute diverticulitis was not increased by a higher consumption of poultry (considered as white meat) (RR for the highest vs lowest quintile, 1.09; 95% CI, 0.86-1.39; P for trend = 0.55).…”

Section: Fiber Intake and Occurrence Of Acute Diverticulitismentioning

confidence: 99%