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Traditionally process planning, scheduling and due date assignment are treated separately. Some works are done on integrated process planning and scheduling and on scheduling with due-date assignment. However integrating all of these functions is not treated. Since scheduling problems alone belong to NP-hard class problems, integrated problems are even harder to solve. In this study process planning and scheduling and SLK due date assignment are integrated using genetic algorithms and Random search techniques. Earliness, Tardiness and length of due-dates are punished. While earliness and tardiness are punished quadratically, due-date is punished linearly. Three results were compared. One is ordinary solution, another one is random search solution and the third one is genetic algorithm solution. Genetic algorithm solution outperforms the other solutions and Random search solution is the second best and ordinary solution is the worst solution. 1

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Introduction: Ado-trastuzumab emtansine (T-DM1) is an antibody–drug conjugate and its survival advantage has been shown in advanced human epidermal growth factor receptor 2 (HER2)–positive breast cancer. However, clinical trials underrepresent patients ⩾65 years of age, leading to a lack of information in this population. We analyzed the real-world outcomes of older women who were treated with T-DM1 therapy. Methods: We performed a multicenter, observational, retrospective analysis of patients aged ⩾65 years treated with T-DM1. A total of 93 patients from 10 cancer centers were involved in the study. Our goal was to determine the survival, response rates, and toxicity profile in T-DM1–treated patients, as well as the factors that influence survival. Results: Median follow-up was 12.2 months. Objective response rate was 29%. Median progression-free survival (PFS) and overall survival (OS) were 8.47 and 15.0 months, respectively. In multivariate analysis, Eastern Cooperative Oncology Group Performance Score 2 was found to be an independent prognostic factor for worse PFS (hazard ratio [HR] 1.81, p = 0.032) and OS (HR 2.33, p = 0.006). Any adverse event (AE) was seen in 92.5% of patients; grade 3 or 4 AEs were seen in 30.1%. Dose reduction or treatment discontinuation rates were 11.8% and 6.5%, respectively. Conclusion: The efficacy of T-DM1 was acceptable and it was generally well-tolerated among older patients with advanced HER2-positive breast cancer.

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Objective: The reactivation rate of chronic hepatitis B virus infection in cancer patients and chemotherapy regimens thought to be associated with hepatitis reactivation were investigated. Patients and Methods: In all, 3,890 cancer patients were included in this study. Mortality rates, chemotherapy regimens, cancer types, number of positive hepatitis serology and reactivation rates were obtained. Results: Only 354 patients had positive hepatitis serology results (HBsAg+). Twenty-four patients (6.7%) with HBsAg positive serology had reactivation. In patients with hepatitis reactivation, the rates of usage of 5-fluorouracil (5-FU), cisplatin, cyclophosphamide, doxorubicin, steroid, rituximab, and vincristine were found to be significantly higher than corresponding rates in patients with positive hepatitis serology results but without hepatitis reactivation (p < 0.05 for all). Conclusion: Increased reactivation rates were detected with usage of 5-FU, cisplatin, cyclophosphamide, doxorubicin, steroid, rituximab, and vincristine.

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GPS (Global Positioning Systems), which have been successfully used to locate and track assets in open areas, cannot show the same performance in closed environments. In cases where GPS cannot provide accurate enough data indoors, indoor positioning systems (IMKS) are being developed. These technologies provide services based on Infrared, Ultrasonic sound and Radio frequency based technologies. Each of indoor positioning technologies suited to be used for specific purposes, although the areas of the shipyard in difficult conditions like all living and inanimate objects required for positioning and monitoring the accuracy, reliability, cost, energy consumption, scalability, and developed a technology that allows other requests could not be convenient. Some technologies perform very well in Energy consumption, while others may be better in terms of coverage area. Therefore, the choice of indoor positioning technology comes across as a multi-purpose decision problem. Among the IMK technologies for shipyard sites with heavy and large medal blocks and other signal interrupting obstacles, it seems that radio frequency-based systems may be more suitable from the point of view of the shipyard site than other technologies. Therefore, in this article, a multi-criteria decision model is being developed to determine which radio-based technologies will be used as Indoor Positioning Technology in Shipyards, and the problem is being solved with Fuzzy MULTIMOORA and Fuzzy COPRAS Methods. An application is being carried out at the SEDEF shipyard.