We studied the effects of tactivin and splenic polypeptides on learning and memory of thymectomized animals. In 3-week rats, thymectomy blocked active avoidance conditioning. Injections of tactivin (0.5 mg/kg) during 1 month after surgery restored learning capacity; splenic polypeptides were ineffective.
Experiments on outbred albino rats showed that tactivin (thymic polypeptide preparation) reduced functional disturbances in active avoidance reaction induced by extra electric current exposure violating the established relationships between the stimuli, reaction, and its result. The preparation provided high level of avoidance reaction after its violation. New effects of immunocorrective agent tactivin were detected. It not only restored the disordered immunological parameters, but also exhibited a pronounced effect on the higher integrative functions of the brain and produced an antistress effect.
Experiments on Wistar rats showed that thymic peptides produce a stress-protective effect that manifested in prevention of functional impairment of conditioned active avoidance response and a decrease in generalized motor activity typical of higher nervous activity failure. We concluded that thymic peptides significantly modulate integrative functions of the brain and produce a stress-protective effect.
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