Effect of Tactivin on Functional Disturbances in Avoidance Reaction in Rats

Киселева, Н. М.; Novoseletskaya, A. V.; Zimina, I. V.; Иноземцев, А. Н.; Arion, V. Ya.

doi:10.1007/s10517-009-0446-x

Cited by 5 publications

(3 citation statements)

References 2 publications

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“…Animals of the treatment groups attained 80% performance by day 3, while control rats and animals receiving spleen polypeptides achieved this level only by day 5. Our data on the positive effects of thymic peptides are consistent with the resuts of previous studies demonstrating acceleration of AAR learning in a shutte box under the effect of tactivin [1,9,10].…”

Section: Resultssupporting

confidence: 91%

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Stress-Protective Effect of Thymic Peptides

et al. 2015

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Experiments on Wistar rats showed that thymic peptides produce a stress-protective effect that manifested in prevention of functional impairment of conditioned active avoidance response and a decrease in generalized motor activity typical of higher nervous activity failure. We concluded that thymic peptides significantly modulate integrative functions of the brain and produce a stress-protective effect.

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Section: Resultssupporting

confidence: 91%

“…The infl uence of CNS on activity of the immune system via the hypothalamic-pituitary-adrenal axis and autonomic system are beyond doubts [11]. Less attention was paid to the effects of the immune system on the CNS that manifested in improvement of cognitive and mnestic processes [7][8][9]. The interaction of these systems is evident during stress.…”

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confidence: 99%

Stress-Protective Effect of Thymic Peptides

et al. 2015

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“…Lately the bidirectional interaction of neuroendocrinal and immune systems has being studied dynamically, and the mechanisms give a possibility to optimize the therapy of some diseases both within the norm and upon aging. The mnemotropic and stress-protective action of the thymus polypeptides Tactivin drug was currently detected [3,5]. As it shown in further studies, the underlying mechanism of such drug effect is activation of serotoninergic and in a less degree, noradrenergic system [4].…”

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confidence: 99%

Stress-Protective Action of Thymus Peptides Concerning Aging Rats

Korolev

Novoseletskaya

Киселева

2019

Medical academic journal

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The survey objective is to check stress-protective action of thymus peptides concerning aging rats, experimentally. Methods used to study anxiety state were applied in tests with 18-months rats. It was found that thymus peptides in elevated plus maze (Thymosin fration 5 (0.5 mg/kg) and Thymulin (0.15 mg/kg)), and anxiolytic Diazepam (0.5 mg/kg) increased the motion activity in open arms, and number of positions onto hind legs in the light part of dark-light chamber. Influence of thymus peptides on the emotional stress associated with the failure of formated conditioned response of active avoidance was studied among aging rats. Within the control the failure caused a sharp decline in avoidance reactions and other demonstration of emotional tension. Thymus peptides and Diazepam prevented negative consequences on avoidance learning reactions. Thus, thymus peptides have demonstrated effect comparable to Diazepam in used models conditions. In avoidance learning model thymus peptides entirely prevented the consequences of emotional stress in ageing rats.

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