Thymus Polypeptide Preparation Tactivin Restores Learning and Memory in Thymectomied Rats

Novoseletskaya, A. V.; Киселева, Н. М.; Zimina, I. V.; Bystrova, O.V.; Ov, Belova; Иноземцев, А. Н.; Arion, V. Ya.; Сергиенко, В. И.

doi:10.1007/s10517-015-3030-6

Cited by 4 publications

(8 citation statements)

References 7 publications

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“…The first reason for the choice is that methyluracil stimulates the recovery of B-lymphocytes [ 13 ]. Peptide preparations based on thymus hormones (thymosin, thymopoietin, thymulin) [ 5 ], and preparations of bone marrow origin (myelopid, leukogen, lenograstim) [ 33 ] do not stimulate the recovery of B-lymphoid cells, while herbal preparations are adaptogens [ 34 , 35 , 36 , 37 , 38 , 39 ]. The second reason for choosing methyluracil is that the ionic compound N,N-dimethyl-N-(2-(methylamino)-2-oxoethyl) propane-1-ammonium iodide (TIC) is structurally more similar to methyluracil (2,4-dioxo-6-methylpyrimidine).…”

Section: Discussionmentioning

confidence: 99%

“…The index of NC cells in the spleen in the placebo group is identical to the index of NC cells in the spleen in the methyluracil group. It is known that when the bone marrow is empty, the spleen begins to perform a compensatory hematopoietic function in the body of an adult human [ 5 , 40 ]. The stress factor in the placebo group stimulates the restoration of hematopoiesis.…”

Section: Discussionmentioning

confidence: 99%

“…The drugs are effective [ 4 ], but they contribute to the intensive division of pathogenic microflora and cancer cells, so they are banned for use in many countries of the world. Thymus preparations (timalin, timogen, and tactivin [ 5 ]) stimulate the proliferation and differentiation of T-lymphocytes, indirectly stimulating B-lymphopoiesis, which induces the synthesis of interferon, tumor necrosis factors, and colony-stimulating factors [ 6 ]. However, thymus preparations stimulate the division of all subpopulations of T-lymphocytes, especially cytotoxic T-lymphocytes, which sometimes causes septic shock.…”

Section: Introductionmentioning

confidence: 99%

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Stimulation of B-Lymphopoiesis by Administration of a Trimecaine-Based Ionic Compound in Cyclophosphamide-Induced Hematopoietic-Depressive Model

et al. 2023

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According to the WHO, the secondary form of hematopoietic-depressive status increases the risk of death in people with oncological, infectious, and hormonal diseases. The choice of drugs that stimulate the hematopoietic activity of B-lymphopoiesis is limited. The current leucopoiesis drugs have a number of side effects: thymic preparations stimulate the production of PGE2, which causes chronic inflammation and various autoimmune diseases through the differentiation of T helper 1 (Th1) cells, the proliferation of Th17 cells, and the production of IL-22 from Th22 cells through EP2 and EP4 receptors; cytokine preparations can cause uncontrolled immune reactions and impaired contractility of smooth and cardiac muscles; drugs based on nucleic acids can stimulate the division of all cells, including bacterial and cancerous ones. The use of oligonucleotides such as ribozymes and antisense oligodeoxynucleotides (AS-ODNs) shows promise as therapeutic moieties, but faces a number of challenges such as nuclease sensitivity, off-target effects, and efficient delivery. The search for substances that stimulate B-lymphopoiesis among ionic compounds was motivated by the discovery of the unique properties of lidocaine docusate, one of the first ionic liquid forms of the known drugs. The lidocaine docusate (protonated form of lidocaine (2-(diethylamino)-N-(2,6-dimethylphenyl) acetamide + docusate-anion (dioctylsulfosuccinate))) suppresses the division of pheochromocytoma cells and activates immunity in rats. The trimecaine-based ionic compound (TIC) demonstrates high B-lymphopoiesis-stimulating activity. The TIC compound stimulates an increase in the volume of transitional B cells, which play an important role for further differentiation and formation of a sufficient number of mature B1 cells and mature B2 cells, where mature B2 cells make up the bulk of the functional population of B lymphocytes. The TIC compound most strongly stimulated the restoration of the number of marginal zone B cells, follicular B cells, and activated germinal center B cells after the cytotoxic emptying of the follicular centers of the spleen induced cyclophosphamide. It significantly exceeds the activity of the comparison drug methyluracil. The TIC compound does not affect the level of pro-B, pre-B-I, or pre-B-II bone marrow cells, which prevents the risk of the formation of immature functionally defective cells.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Stimulation of B-Lymphopoiesis by Administration of a Trimecaine-Based Ionic Compound in Cyclophosphamide-Induced Hematopoietic-Depressive Model

et al. 2023

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“…To investigate the role of the thymus in muscle growth, we removed the thymus from adult mice according to a previously reported protocol (32)(33)(34). Four months after the operation, the mice showed reduced body weights compared to those of control mice (with sham operation), but the lean weights were comparable (p > 0.05) (Fig.…”

Section: The Thymus Is Necessary For Skeletal Muscle Regenerationmentioning

confidence: 99%

The thymus regulates skeletal muscle regeneration by directly promoting satellite cell expansion

Zheng

Wang

Chen

et al. 2022

Journal of Biological Chemistry

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“…Pharmacological treatments are initially recommended when non-pharmacological options do not attain satisfying sleep (14). Currently, the commonly used ageing animal models include: D-galactose (D-gal)-induced subacute (15), β-amyloid induced (16,17), thymic senescence (18), rapid (19) and natural (20) ageing models. The ageing model induced by D-gal has been widely used (21,22) and has been evaluated in behavioral, biochemical and neurochemical aspects (23).…”

Section: Introductionmentioning

confidence: 99%

Establishment of a rat model with ageing insomnia induced by D‑galactosef and para‑chlorophenylalanine

et al. 2020

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The current study aimed to establish a rat model of ageing insomnia induced by D-galactose and/or para-chlorophenylalanine. Following establishment of the model, body weights were measured, and Morris water maze and pentobarbital-induced sleep tests were performed. The serum levels of inflammatory mediators and the neural levels of neurotransmitters were detected. The results demonstrated that the body weights of PCPA+D-gal-induced ageing insomnia rats decreased significantly. Ageing insomnia rats exhibited longer latencies to the platform in the Morris water maze tests and fewer target crossings. The sleep latency of the model rats was longer and sleep time was shorter by contrast. The relative expression of hippocampal IL-6, TNF-α, NF-κB and mGluR2 mRNA of the PCPA+D-gal-induced ageing insomnia group was higher, while the relative expression of 5-HT 1A R and GABA A R a1 mRNA were lower. The serum levels of IL-1β, IL-6, TNF-α and brain level of glutamate increased in the PCPA+D-gal-induced ageing insomnia group, while the levels of 5-HT and GABA decreased. In conclusion, memory function, sleep time, expression of inflammatory factors and neurotransmitters are altered in ageing insomnia rats induced by D-galactose and para-chlorophenylalanine, indicating the successful establishment of a murine model of ageing insomnia.

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Thymus Polypeptide Preparation Tactivin Restores Learning and Memory in Thymectomied Rats

Cited by 4 publications

References 7 publications

Stimulation of B-Lymphopoiesis by Administration of a Trimecaine-Based Ionic Compound in Cyclophosphamide-Induced Hematopoietic-Depressive Model

Stimulation of B-Lymphopoiesis by Administration of a Trimecaine-Based Ionic Compound in Cyclophosphamide-Induced Hematopoietic-Depressive Model

The thymus regulates skeletal muscle regeneration by directly promoting satellite cell expansion

Establishment of a rat model with ageing insomnia induced by D‑galactosef and para‑chlorophenylalanine

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