Two classes of gamma-ray bursts have been identiÐed so far, characterized by durations shorter T 90 and longer than approximately 2 s. We show here that the BATSE 3B data allow a good Ðt with three Gaussian distributions in logThe s2 statistic indicates a 40% probability for two-Gaussian Ðts, T 90 . whereas the three-Gaussian Ðt probability is 98%. Using another statistical method, it is argued that the probability that the third class is a random Ñuctuation is less than 0.02%.

Gamma-ray bursts can be divided into three groups ("short", "intermediate", "long") with respect to their durations. This classification is somewhat imprecise, since the subgroup of intermediate duration has an admixture of both short and long bursts. In this paper a physically more reasonable definition of the intermediate group is presented, using also the hardnesses of the bursts. It is shown again that the existence of the three groups is real, no further groups are needed. The intermediate group is the softest one. From this new definition it follows that 11% of all bursts belong to this group. An anticorrelation between the hardness and the duration is found for this subclass in contrast to the short and long groups. Despite this difference it is not clear yet whether this group represents a physically different phenomenon.

Abstract. Two classes of gamma-ray bursts have been identified so far, characterized by durations shorter and longer than about 2 s. In 1998 two independent papers indicated the existence of the third class of the bursts with duration between approximately 2 and 10 s. In this paper, using the full BATSE Catalog, the maximum likelihood estimation is presented, which gives a 0.5% probability for having only two subclasses. A Monte-Carlo simulation also confirms this probability.

Blebbistatin is a commonly used molecular tool for the specific inhibition of various myosin II isoforms both in vitro and in vivo. Despite its popularity, the use of blebbistatin is hindered by its poor water-solubility (below 10 micromolar in aqueous buffer) and blue-light sensitivity, resulting in the photoconversion of the molecule, causing severe cellular phototoxicity in addition to its cytotoxicity. Furthermore, blebbistatin forms insoluble aggregates in water-based media above 10 micromolar with extremely high fluorescence and also high adherence to different types of surfaces, which biases its experimental usage. Here, we report a highly soluble (440 micromolar in aqueous buffer), non-fluorescent and photostable C15 amino-substituted derivative of blebbistatin, called para-aminoblebbistatin. Importantly, it is neither photo- nor cytotoxic, as demonstrated on HeLa cells and zebrafish embryos. Additionally, para-aminoblebbistatin bears similar myosin II inhibitory properties to blebbistatin or para-nitroblebbistatin (not to be confused with the C7 substituted nitroblebbistatin), tested on rabbit skeletal muscle myosin S1 and on M2 and HeLa cells. Due to its drastically improved solubility and photochemical feature, as well as lack of photo- or cytotoxicity, para-aminoblebbistatin may become a feasible replacement for blebbistatin, especially at applications when high concentrations of the inhibitor or blue light irradiation is required.

According to the cosmological principle, Universal large-scale structure is homogeneous and isotropic. The observable Universe, however, shows complex structures even on very large scales. The recent discoveries of structures significantly exceeding the transition scale of 370 Mpc pose a challenge to the cosmological principle.We report here the discovery of the largest regular formation in the observable Universe; a ring with a diameter of 1720 Mpc, displayed by 9 gamma ray bursts (GRBs), exceeding by a factor of five the transition scale to the homogeneous and isotropic distribution. The ring has a major diameter of 43 o and a minor diameter of 30 o at a distance of 2770 Mpc in the 0.78 < z < 0.86 redshift range, with a probability of 2 × 10 −6 of being the result of a random fluctuation in the GRB count rate.Evidence suggests that this feature is the projection of a shell onto the plane of the sky. Voids and string-like formations are common outcomes of large-scale structure. However, these structures have maximum sizes of 150 Mpc, which are an order of magnitude smaller than the observed GRB ring diameter. Evidence in support of the shell interpretation requires that temporal information of the transient GRBs be included in the analysis.This ring-shaped feature is large enough to contradict the cosmological principle. The physical mechanism responsible for causing it is unknown.

Context. Research over the past three decades has revolutionized cosmology while supporting the standard cosmological model. However, the cosmological principle of Universal homogeneity and isotropy has always been in question, since structures as large as the survey size have always been found each time the survey size has increased. Until 2013, the largest known structure in our Universe was the Sloan Great Wall, which is more than 400 Mpc long located approximately one billion light years away. Aims. Gamma-ray bursts (GRBs) are the most energetic explosions in the Universe. As they are associated with the stellar endpoints of massive stars and are found in and near distant galaxies, they are viable indicators of the dense part of the Universe containing normal matter. The spatial distribution of GRBs can thus help expose the large scale structure of the Universe. Methods. As of July 2012, 283 GRB redshifts have been measured. Subdividing this sample into nine radial parts, each containing 31 GRBs, indicates that the GRB sample having 1.6 < z < 2.1 differs significantly from the others in that 14 of the 31 GRBs are concentrated in roughly 1/8 of the sky. A two-dimensional Kolmogorov-Smirnov test, a nearest-neighbour test, and a Bootstrap Point-Radius Method explore the significance of this clustering. Results. All tests used indicate that there is a statistically significant clustering of the GRB sample at 1.6 < z < 2.1. Furthermore, this angular excess cannot be entirely attributed to known selection biases, making its existence due to chance unlikely. Conclusions. This huge structure lies ten times farther away than the Sloan Great Wall, at a distance of approximately ten billion light years. The size of the structure defined by these GRBs is about 2000-3000 Mpc, or more than six times the size of the largest known object in the Universe, the Sloan Great Wall.

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Context. Two classes of gamma-ray bursts have been identified in the BATSE catalogs characterized by durations shorter and longer than about 2 s. There are, however, some indications for the existence of a third class. Swift satellite detectors have different spectral sensitivity than pre-Swift ones for gamma-ray bursts. Therefore we reanalyze the durations and their distribution and also the classification of GRBs. Aims. We analyze the bursts duration distribution, published in The First BAT Catalog, whether it contains two, three or more groups. Methods. Using The First BAT Catalog the maximum likelihood estimation was used to analyze the duration distribution of GRBs.Results. The three log-normal fit is significantly (99.54% probability) better than the two for the duration distribution. Monte-Carlo simulations also confirm this probability (99.2%). Similarly, in previous results we found that the fourth component is not needed. The relative frequencies of the distribution of the groups are 7% short 35% intermediate and 58% long. Conclusions. Similarly to the BATSE data, three components are needed to explain the BAT GRBs' duration distribution. Although the relative frequencies of the groups are different than in the BATSE GRB sample, the difference in the instrument spectral sensitivities can explain this bias. This means theoretical models may be needed to explain three different type of gamma-ray bursts.