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The in vitro experiment, involving 1164 strains of the tuberculosis mycobacteria, exhibited a potentiating effect of silver nanoparticles on known antituberculous preparations in respect of overcoming drug-resistance of the causative agent. The in vitro experiment, based on the model of resistant tuberculosis, was performed on 65 white mice. An evident antituberculous effect of the nanocomposite on the basis of silver nanoparticles and isoniazid was proved. Toxicological assessment of the of nanopreparations was carried out. The performed research scientifically establishes efficacy and safety of the nanocomposite application in combination therapy of patients suffering from drug-resistant tuberculosis. Tuberculosis problemThe current trait of the problem is expressed in extremely low efficacy in treatment of patients, particularly, concerning those who are diagnosed on a result of their visit to a doctor. In many cases the efficacy falls below 30%, which proves low efficiency of treatment rate of the modern strategy in tuberculosis treatment [5,11]. The main reason lies in drug resistance of the tuberculosis mycobacterium to the existing numerous drugs, which to a large degree have lost their potency [7]. In Russia milliards of roubles are spent on free treatment of tuberculosis every year. Due to drug resistance considerable part of the sponsored funds, before the treatment starts, can be regarded and planned as useless and futile expenses. Ineffective treatment promotes formation and occurrence of "new" tuberculosis, called chemo-resistant. The research objective is to evaluate efficacy, safety and tolerance of the silver nanoparticles in isolated form as well as in joint application with the antituberculous preparation isoniazid in vitro and in vivo research during treatments of experimental drug-resistance cattle tuberculosis Treatment and nanoparticles of silverOne of the ways out of the existing situation might be the search for the means to reverse the known antituberculosis preparations directed at overcoming the tuberculosis mycobacteria resistance during their interaction with the chemi-pharmacological agents. The nanoparticles of silver are discussed to be such an agent . The history of the scientific research of silver proves its pronounced antiseptic properties. The history of silver research studies established that the daily diet of a man should contain on average 80 micrograms of silver, since the latter is a microelement essential for maintaining normal metabolism as well as regular functioning of his immune system. The same research proved that the doses of silver in the volume of 50 -250 mg per liter are physiological and during prolonged consumption have no negative effect on the human organism. Mechanism of bactericidal action of nanosilverThe main function of the silver nanoparticIes is a continuous accumulation of silver ion s in the vicinity of the affected area. This is to protect the silver ions from the interaction with the anions of salts in the blood, and thereby increase the ther...

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