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Advances in polyhydroxyphenol chemistry are a result of the development of new experimental techniques, especially methods for detection and determination of these compounds. Small-scale procedures are valuable for establishing the concentration and the constitution of polyhydroxyphenols in plant products.Various spectrophotometric and colorimetric rneth~dsl-~ have been reported for the small-scale determination of polyhydroxyphenols. A spectrophotometric method6 has been developed for the determination of catechol, :resorcinol and phloroglucinol with the use of potassium iodate in dilute nitric acid.In this investigation hydroquinone, pyrogallol and resorcinol were determined spectrophotometrically, after heating with sodium carbonate solution in a boiling water-bath for about 15 min. The method is convenient and precise.

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Ke yw o r d s : A n tima la ria I am in oq uin olin e de term in a tio n ; back-titra tion; ammonium me ta vana da te Aminoquinoline derivatives are common drugs in the treatment of malaria. The determination of antimalarials has been reported by several workers: Sane et al. 1 described a spectrophotometric method for the determination of amodiaquine hydrochloride by reaction with bromophenol blue, bromocresol green, methyl orange and bromocresol purple, and recently, Srivastava et aZ.2 determined some antimalarial drugs using N-chlorosuccinimide and potassium hexacyanoferrate(II1) reagents. In this paper we describe a convenient method for the determination of some antimalarial aminoquinoline derivatives, in the pure form and in pharmaceutical preparations, using ammonium metavanadate (NH,VO,) solution as an oxidising agent. The method is of general applicability and is quick and simple compared with established pr0cedures.3~4 Paper A31272

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