Determination of some antimalarial aminoquinolines by vanadium(V) titration

Abstract

Ke yw o r d s : A n tima la ria I am in oq uin olin e de term in a tio n ; back-titra tion; ammonium me ta vana da te Aminoquinoline derivatives are common drugs in the treatment of malaria. The determination of antimalarials has been reported by several workers: Sane et al. 1 described a spectrophotometric method for the determination of amodiaquine hydrochloride by reaction with bromophenol blue, bromocresol green, methyl orange and bromocresol purple, and recently, Srivastava et aZ.2 determined some antimalarial drugs using N-chlorosuccinimide and potassium hexacyanoferrate(II1) reagents. In this paper we describe a convenient method for the determination of some antimalarial aminoquinoline derivatives, in the pure form and in pharmaceutical preparations, using ammonium metavanadate (NH,VO,) solution as an oxidising agent. The method is of general applicability and is quick and simple compared with established pr0cedures.3~4 Paper A31272