The novel ligand 2-[2 ' -(6-methoxybenzothiazolyl)azo]-3,5-dimethyl benzoic acid (6-MBTAMB), derived from 2-amino-6-methoxy benzothiazole, has been used to synthesize a series of new metal complexes of Ag(I), Pt(IV) and Au(III). The metal complexes were characterized by elemental analyses (CHNS), molar conductivity, crystal structure (XRD), spectroscopic techniques: FT-IR, 1 H NMR, 13 C NMR, UV-Vis, mass spectra, thermal analysis (TG-DTA), FE-SEM and magnetic properties. Results con rmed that the azo dye ligand behaves a tridentate and coordinates to the metal ion via nitrogen atom of azomethine group of heterocyclic benzothiazole ring, nitrogen atom of the azo group which is the farthest of the benzothiazole molecule and carboxylic oxygen. Antimicrobial properties of all newly synthesized azo compounds are also demonstrated against bacterial pathogenic organisms and fungi. These complexes are more effective against bacteria and less effective against fungi compared to standard antibacterial drugs (Novobiocin) and antifungal drugs (Cycloheximide). By using the DPPH (2,2-diphenyl-1-picrylhydrazyl) radical scavenging test, it was discovered that the complexes had good antioxidant properties. In addition, the (6-MBTAMB) and metal complexes were docked with the crystal structure of FGF Receptor 2 (FGFR2) kinase domain harboring the pathogenic gain of function K659E mutation identi ed in endometrial cancer using the Molecular Operating Environment module (MOE). In vitro studies on human endometrial cancer cell lines (MFE-296) as well as healthy human umbilical vein endothelial cells (HUVEC) show uptake of the intact compounds by the cancer cells and increased activity against the cancer cells.
HighlightDiazo-coupling was used to synthesize the heterocyclic azo dye ligand (6-MBTAMB).Newly synthesized azo compounds have been con rmed by various spectroscopic techniques.Antimicrobial, antioxidant, anticancer, and molecular docking were used to evaluate 6-MBTAMB with metal complexes. MFE-296 cells were more responsive to 6-MBTAMB and Au(III)-Complex Cytotoxicity with IC 50 of 6-MBTAMB is 100.4 µg/ml and Au(III) metal complex is 43.44 µg/ml in MFE-296 cell line.
This study focuses on the synthesis of the 2-[2\-(5-bromo thiazolyl) azo]-5-di-methyl amino benzoic acid (5-BrTAMB) and Cd(II) coordinate complex. Diazotization by 2-amino-5-bromo thiazole and mixation by an alkaline alcohol solution of the 3-dimethyl amino benzoic acid. Various analytical techniques, including 1H-NMR, mass spectral, FT-IR spectra, UV-Vis, elemental analysis (C.H.N.S), measurement of electrical conductivity, magnetic susceptibility, TGA, XRD data and SEM spectra support azo ligand structures and their metal complex. The ligand is the trident N, N, O donor and forms the ML2 [metal-ligand] stoichiometry complex. Cd(II)-complex is found to have exhibited octahedral geometry. The ligand and its metal complex were screened against A. Niger for their antifungal activity and antibacterial activity against S. Aurores and E. Coli.
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