Synthesis, Characterization and Biological Activity Studies of Cadmium (II) Complex Derived from Azo Ligand 2-[2^\-(5-Bromo Thiazolyl) Azo]-5-Dimethyl Amino Benzoic Acid

Abstract

This study focuses on the synthesis of the 2-[2\-(5-bromo thiazolyl) azo]-5-di-methyl amino benzoic acid (5-BrTAMB) and Cd(II) coordinate complex. Diazotization by 2-amino-5-bromo thiazole and mixation by an alkaline alcohol solution of the 3-dimethyl amino benzoic acid. Various analytical techniques, including 1H-NMR, mass spectral, FT-IR spectra, UV-Vis, elemental analysis (C.H.N.S), measurement of electrical conductivity, magnetic susceptibility, TGA, XRD data and SEM spectra support azo ligand structures and their metal complex. The ligand is the trident N, N, O donor and forms the ML2 [metal-ligand] stoichiometry complex. Cd(II)-complex is found to have exhibited octahedral geometry. The ligand and its metal complex were screened against A. Niger for their antifungal activity and antibacterial activity against S. Aurores and E. Coli.

Synthesis, Characterization, in silico DFT, Molecular docking, ADMET Profiling Studies and Toxicity Predictions of Ag(I) Complex Derived from 4‐Aminoacetophenone

“…The spectra of Ag(I) complex are altered by complexation at oxygen due to the change in shape of the (OH) band. This is assignable to the broking of hydrogen bonds by the effect of metal ion and the involvement of the oxygen atom in coordination [51] . Moreover, the spectra of the free ligand exhibit additional spectral bands at (3126 and 3046) cm −1 and (3120 and 2924) cm −1 correspond to υ(C‐H armatic ) and υ(C‐H aliphatic ) for (DMPDE) and Ag(I) complex respectively.…”

“…This is assignable to the broking of hydrogen bonds by the effect of metal ion and the involvement of the oxygen atom in coordination. [51] Moreover, the spectra of the free ligand exhibit additional spectral bands at (3126 and 3046) cm À 1 and (3120 and 2924) cm À 1 correspond to υ(C-H armatic ) and υ(C-H aliphatic ) for (DMPDE) and Ag(I) complex respectively. The appearance of stretching vibration is characterized by υ(CÀ H), It is confirmed that the ligand conforms to an azo structure does not form a hydrazo structure and reacts with metal ions through the azo moiety.…”

Synthesis, spectral characterization, lethal dose (LD50) and acute toxicity studies of 1,4-Bis(imidazolylazo)benzene (BIAB)

“…The findings showed that the form of compensated compound groups, for example, the group (-N=N-and N-H), in the studied ligand [48][49][50], influence the degree of efficacy and the bacteria type influencing them. Fungi, on the other hand, indicated that the majority of the compound tested had moderate to weak active ingredients (inhibition zones ranged from 6 to 9 mm) [51].…”

Preparation complexes Co(III), Ni(II), and Cu(II) with novel azo-Schiff base ligand (N, N, O) derived from 2- amino- 6- methoxy benzothiazole with spectral characterization, study biological activity as anti-cancer, anti-oxidant to complexes

“…The ligand (HL) was prepared based on what was prepared in our laboratory by Al-Adly and his group with some modifications to the method of work; Schiff base was prepared through a condensation reaction between the compound 4-Dimethylamine benzaldehyde and its molar equivalent (1:2) of the compound 3-aminophenol, like 1.2 g (0.01 mol) of 4-dimethylamine benzaldehyde was dissolved in 40 ml of absolute ethanol and mixed with a solution of 1.2 g (0.01 mol) of 3-aminophenol dissolved in 30 ml of the same mentioned solvent. Four drops of glacial acetic acid were added as a catalyst, followed by heating the mixture for (10-12) hours; the solution was left to cool and then poured over ice pieces of distilled water where pale-yellow crystals appeared, filtered, dried, and returned Crystallized with hot ethanol to obtain a base lip (Jaber et al 2021). (Al-adilee and Hessoon 2019) • Preparation of azo ligand -Schiff base (HL.)…”