This study focuses on the synthesis of the 2-[2\-(5-bromo thiazolyl) azo]-5-di-methyl amino benzoic acid (5-BrTAMB) and Cd(II) coordinate complex. Diazotization by 2-amino-5-bromo thiazole and mixation by an alkaline alcohol solution of the 3-dimethyl amino benzoic acid. Various analytical techniques, including 1H-NMR, mass spectral, FT-IR spectra, UV-Vis, elemental analysis (C.H.N.S), measurement of electrical conductivity, magnetic susceptibility, TGA, XRD data and SEM spectra support azo ligand structures and their metal complex. The ligand is the trident N, N, O donor and forms the ML2 [metal-ligand] stoichiometry complex. Cd(II)-complex is found to have exhibited octahedral geometry. The ligand and its metal complex were screened against A. Niger for their antifungal activity and antibacterial activity against S. Aurores and E. Coli.
In this paper we report the synthesis and identification of Ni(II), Cu(II) and Zn(II) complexes with new thiazole based azo dye 2-[2'-(5-methyl thiazolyl)azo]-5-dimethyl amino benzoic acid (5-MeTAMB) by the diazotization of 2-amino-5-methyl thiazole and coupling with 3-dimethyl amino benzoic acid in alkaline alcoholic solution. The structures of the azo dye ligand and its metal complexes were confirmed by various analytical techniques like by elemental analysis (C.H.N.S), UV-visible, FT-IR spectroscopic, mass spectroscopic, Asian Journal of Chemistry; Vol. 30, No. 7 (2018), 1537-1545 microbial activities such as antibacterial [17], antiviral [18] and antifungal [19]. In this work describe the preparation and characterization of new thiazolylazo ligand (5-MeTAMB) and its complexes with Ni(II), Cu(II) and Zn(II) ions, is described biological activities (antibacterial and antifungal). The thiazolylazo ligand and its Cu(II) complex evaluated for in vitro anticancer activity against human breast cancer MCF7 by MTT assay.
EXPERIMENTALAll the chemicals and solvents were of the highest purity obtained from BDH, Aldrich, sigma and Merck. Mass spectra was obtained using a Shimadzu Agilent Technologies 5973C at 70 e and MSD energy using a direct insertion probe (Acq method 10 W energy) at temperature 90-110 °C.
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