A series of isatins incorporating thiazole, thiadiazole, benzothiazole and p-toluene sulfonyl hydrazide moieties, along with their cobalt(II), copper(II), nickel(II) and zinc(II) metal complexes have been synthesized and characterized by elemental analyses, molar conductances, magnetic moments, IR, NMR and electronic spectral data. These compounds have been screened for antibacterial activity against Escherichia coli, Bacillus subtillis, Shigella flexneri, Staphylococcus aureus, Pseudomonas aeruginosa and Salmonella typhi, and for antifungal activity against Trichophyton longifusus, Candida albicans, Aspergillus flavus, Microsporum canis, Fusarium solani and Candida glaberata using the agar-well diffusion method. All the synthesized compounds have shown good affinity as antibacterial and/or antifungal agents which increased in most of the cases on complexation with the metal ions.
2-Amino-1,3,4-thiadiazole undergoes a condensation reaction with furane-, thiophene- and pyrrole-2-carboxaldehyde to form tridentate NNO, NNS and NNN donor Schiff bases. These Schiff bases were further used to obtain complexes of the type [M(L)2]X, where M = Co(II), Cu(II), Ni(II) or Zn(II), L = L1, L2 or L3 and X = Cl2. The new compounds described here have been characterized by their physical, spectral and analytical data, and have been screened for antibacterial activity against several bacterial strains such as Escherichia coli, Staphylococcus aureus, and Pseudomonas aeruginosa. The antibacterial potency of the Schiff bases increased upon chelation/complexation in comparison to the uncomplexed Schiff bases against the tested bacterial species thus, opening new approaches to find new ways in the fight against antibiotic-resistant strains.
Organometallic-based, 1,1'-diacetylferrocene-derived antibacterial and antifungal thiocarbohydrazone, carbohydrazone, thiosemicarbazone and semicarbazone have been prepared by condensing equimolar amount of 1,1'-diacetylferrocene with thiocarbohydrazide, carbohydrazide thiosemicarbazide and semicarbazide, respectively. These were used as ligands for the preparation of their cobalt (II), copper (II), nickel (II) and zinc (II) metal complexes. All the synthesized ligands and their complexes were characterized by IR, NMR, elemental analyses, molar conductances, magnetic moments and electronic spectral data. These synthesized compounds were screened for their antibacterial activity against Escherichia coli, Bacillus subtillis, Staphylococcus aureus, Pseudomonas aeruginosa and Salmonella typhi, and for antifungal activity against Trichophyton longifusus, Candida albicans, Aspergillus flavus, Microsporum canis, Fusarium solani and Candida glaberata using the agar-well diffusion method. All the compounds showed good antibacterial and antifungal activity which increased on coordination with the metal ions thus, introducing a novel class of organometallic-based antibacterial and antifungal agents.
A field experiment was conducted at Central Cotton Research Institute, Multan, Pakistan on Miani soil series, silt loam soil (Calcaric, Cambisols and fine silty, mixed Hyperthermic Fluventic Haplocambids) to assess the response of four cotton (Gossypium hirsutum L.) cultivars to potassium (K) fertilization. The treatments consisted of four cotton cultivars (CIM-448, CIM-1100, NIAB-Karishma, S-12), four potassium rates (0, 62.5, 125, 250 kg K ha À1 ), and two sources of potassium fertilizer [muriate of potash (KCl) and sulphate of potash (K 2 SO 4 )]. The cotton cultivars differed ORDER REPRINTS significantly in response to various potassium fertilizer levels and its sources with respect to seed cotton yield and its components. The highest yield was obtained with the application of 250-kg K ha À1 , however, it was economical to add 125 kg K ha À1 . Seed cotton yield of cv. CIM-448 was considerably greater than that of the other cultivars in K-unfertilized treatments, which was related to cultivar differences in K uptake efficiency in utilizing native potassium nutrient. Potassium added as muriate of potash caused a significant depression in seed cotton yield than that of sulphate of potash. The increase in yield seemed to have resulted largely from the higher K concentration of leaf tissues at bloom stage and available soil-K because of potassium application. A significant relationship between the yield and number of bolls per plant (r ¼ 0.92 ÃÃ ) and boll weight (r ¼ 0.85 ÃÃ ) indicated that these two growth attributes were responsible for enhancing the quantum of final harvest of seed cotton.
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