No abstract

A series of 29 previously reported N 4 -substituted 5-nitroisatin-3-thiosemicarbazones 2-30 has been screened for leishmanicidal potential. 7,8,[10][11][12][13][15][16][17][18][19]21,23,24,26,28 and 30 exhibited good to excellent antileishmanial activities with IC 50 values ranging from 0.44 AE 0.02 to 32.38 AE 0.66 mg/mL. Of these, 5, 7, 19 and 28 proved to be the most active antileishmanial agents, displaying activities with IC 50 values 1.78 AE 0.35, 0.44 AE 0.02, 1.91 AE 0.04 and 4.28 AE 0.75 mg/mL, respectively, which were even better than the standard drug, pentamidine (IC 50 ¼ 5.09 AE 0.04 mg/mL). This study presents the first example of exhibition of leishmanicidal potential by isatin-thiosemicarbazones and as such furnishes a solid basis for further research on these compounds to develop more potent antileishmanial agents.

No abstract

In the title compound, C15H19N5O3S, intra­molecular N—H⋯O, N—H⋯N and C—H⋯S inter­actions occur and the three terminal C atoms of the hexyl group are disordered over two sites with an occupancy ratio of 0.664 (12):0.336 (12). In the crystal, inversion dimers linked by pairs of N—H⋯O hydrogen bonds occur and C—H⋯O bonds link the dimers into chains. A short C=O⋯π contact is also present.

In the title compound, C16H13N5O3S·CH4O, the dihedral angle between the isatin unit and the 2-methyl­phenyl group is 41.81 (2)° and intra­molecular N—H⋯O and N—H⋯N hydrogen bonds occur, generating S(6) and S(5) rings, respectively. In the crystal, polymeric chains arise as a result of N—H⋯O, O—H⋯S and C—H⋯O inter­actions.

Pakistan has a variety of privately managed schools. Inspired by thecorporate model the large school systems offer franchise to the smallschools in the name of better quality education leading to better marketacceptability. This study was conducted to find out the difference in thequality of education provided by the franchise and independent privatesecondary schools. Ten schools of a renowned large spread schoolsystem were selected conveniently and ten independent schools wereselected from the same localities for ensuring similarity of the context.Quality of education was define dalong input, process and product/outputindicators. Opinion of Head Teachers (HTs)/ School principals wasgathered through a questionnaire consisting five point rating scale oninput and process indicators. Opinion of HTs about input indicators wasvalidated through direct observation of the input indicators in the schoolsby one of the researchers. Students’ achievement scores in thematriculation examination conducted by the Board of Intermediate andSecondary Education, Lahore were the indicator of quality output. TheHTs of the two types of schools perceived no significant difference in thequality of input and process at their schools but the independent schoolsscoring slightly better on each of the two indicators. However, theindependent private schools were significantly superior to the franchiseschools in quality of output in terms of students’ pass percentage anddistribution over grades. Thus, the claim of franchising for better qualityeducation was not supported by this research.

In the title compound, C15H10FN5O3S, an intra­molecular N—H⋯N hydrogen bond generates an S(5) ring, whereas N—H⋯O and C—H⋯S inter­actions complete S(6) ring motifs. The dihedral angle between the isatin ring system and the fluoro­benzene ring is 5.96 (6)° and the complete mol­ecule is close to planar (r.m.s. deviation for all the non-H atoms = 0.112 Å). In the crystal, mol­ecules are linked by N—H⋯O hydrogen bonds to form C(8) chains along the [100] direction and C—H⋯O inter­actions are also observed.