Organometallic-based antibacterial and antifungal compounds: transition metal complexes of 1,1′-diacetylferrocene-derived thiocarbohydrazone, carbohydrazone, thiosemicarbazone and semicarbazone

Abstract

Organometallic-based, 1,1'-diacetylferrocene-derived antibacterial and antifungal thiocarbohydrazone, carbohydrazone, thiosemicarbazone and semicarbazone have been prepared by condensing equimolar amount of 1,1'-diacetylferrocene with thiocarbohydrazide, carbohydrazide thiosemicarbazide and semicarbazide, respectively. These were used as ligands for the preparation of their cobalt (II), copper (II), nickel (II) and zinc (II) metal complexes. All the synthesized ligands and their complexes were characterized by IR, NMR, elemental analyses, molar conductances, magnetic moments and electronic spectral data. These synthesized compounds were screened for their antibacterial activity against Escherichia coli, Bacillus subtillis, Staphylococcus aureus, Pseudomonas aeruginosa and Salmonella typhi, and for antifungal activity against Trichophyton longifusus, Candida albicans, Aspergillus flavus, Microsporum canis, Fusarium solani and Candida glaberata using the agar-well diffusion method. All the compounds showed good antibacterial and antifungal activity which increased on coordination with the metal ions thus, introducing a novel class of organometallic-based antibacterial and antifungal agents.

A new azo‐Schiff base: Synthesis, characterization, biological activity and theoretical studies of its complexes

“…[9][10][11][12][13] Thus, they play an important role in revealing the preferred coordination geometries of metal complexes due to their preparative accessibility, diversity and structural variability. [14][15][16] These properties of Schiff bases and their complexes have resulted in wide applications in the biological field [17] Cu (II) complexes are known to be effective against rheumatoid arthritis and they also show anti-ulcer activity. [18] This is because gastrointestinal irritation often precludes treatment by other antiarthritic drugs.…”

Preparation, characterization and Microbicide activities of N'-((3-(hydroxyimino)butan-2-ylidene)-2-(phenylamino)acetohydrazide and its complexes

“…The magnetic moment values of copper(II) complexes (2) and (10) recorded 1.91 and 2.01 B.M, which are consistent with the presence of one unpaired electron of copper(II) ions in a square planar environment [66][67][68]. The lower magnetic moment of complex (9) than the expected values reported for square planar copper complexes is related to spin-spin interactions between the copper ions [69].…”

Synthesis, characterization and antimicrobial activities of some mixed ligand complexes of Co(II) with thiosemicarbazones and N-protected amino acids

“…The complexes were analysed for their cobalt content employing standard literature procedure [21] after destroying the organic matter first with aqua regia and then with concentrated sulphuric acid. Sulfur was estimated gravimetrically as BaSO 4 . Elemental analyses were carried out on a Elemental Vario EL III Carlo Erba 1108 analyzer.…”