A novel approach for the synthesis of indolizines from 2-(pyridin-2-yl)acetates, ynals, and alcohols or thiols has been developed. This MCR (multicomponent reaction) that proceeds under the solvent- and metal-free conditions has provided a straightforward path to construct indolizines. Furthermore, this reaction demonstrates other attractive features such as widely available starting materials, mild conditions, good functional group tolerance, and high efficiency.
The chemical reagents were obtained from Aladdin L.L.C. and used without further purification.TLC detection was performed on pre-coated glass plates. Silica gel (200-300 mesh) was used for column chromatography. NMR spectra were perfurmed on a Bruker-ARX 600 instrument at 26 o C. MS spectra were obtained on Bruker mass spectrometer. Compound 1 was prepared by the literature method (Liu, J.
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