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Abstract-High-performance libraries, the performancecritical building blocks for high-level applications, will assume greater importance on modern processors as they become more complex and diverse. However, automatic library generators are still immature, forcing library developers to manually tune library to meet their performance objectives.We are developing a new script-controlled compilation framework to help domain experts reduce much of the tedious and error-prone nature of manual tuning, by enabling them to leverage their expertise and reuse past optimization experiences. We focus on demonstrating improved performance and productivity obtained through using our framework to tune BLAS3 routines on three GPU platforms: up to 5.4x speedups over the CUBLAS achieved on NVIDIA GeForce 9800, 2.8x on GTX285, and 3.4x on Fermi Tesla C2050. Our results highlight the potential benefits of exploiting domain expertise and the relations between different routines (in terms of their algorithms and data structures).

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