The authors demonstrate detection and mapping of brain magnetic fields evoked by auditory stimulation with a noncryogenic magnetometer based on spin precession of potassium atoms in spin-exchange-relaxation-free regime. Optical readout using a photodiode array allows flexibility in detector placement while using common elements for most components of the multichannel system. Absence of a cryogenic dewar eliminates magnetic Johnson noise from radiation shields and allows the use of a compact magnetic shield with a high shielding factor. The magnetometer sensitivity is currently equal to 3.5 fT/ Hz 1/2 at 10 Hz, similar to superconducting quantum interference device magnetoencephalography systems.
The present study evaluated the expression of key molecules and the status of DNA in both oral squamous cell carcinoma (OSCC) and adjacent tissues to establish a molecular surgical boundary and provide a cancer progression model. Biopsy samples from 50 OSCC patients were divided into T (cancer), P1 (0–0.5 cm), P2 (0.5–1 cm), P3 (1–1.5 cm) and P4 (1.5–2 cm) groups based on the distances from the visible boundary of the primary focus. Twenty samples of normal mucosa were used as controls. We used immunohistochemical staining and flow cytometry to evaluate p53, p21
CIP1/WAF1
, eIF4E and Ki-67 expression and to determine DNA status, respectively. Sub-mucosal invasion was present in the P1 and P2 groups as determined by haematoxylin and eosin staining. Mutant p53 expression decreased gradually from cancerous to normal mucosae, whereas p21
CIP1/WAF1
expression displayed an opposite trend. eIF4E expression decreased from cancerous to normal mucosae. Ki-67 expression, the heteroploidy ratio, S-phase fraction and proliferative index decreased gradually with the distance from the tumour centre. Based on these results, we suggest that the resection boundary in OSCC surgery should be beyond 2 cm from the tumour. Additionally, the adjacent tissues of the primary focus could be used as a model for assessing cancer progression.
Using femtosecond transient absorption spectroscopy on excited-state helium atoms in a plasma created through optical field ionization, we measured the decay of 2(3)S-2(3)P excitation with sub-ps temporal resolution. The population evolution shows that initial decay is significantly faster than the electron-atom collisions and three orders of magnitude faster than the single atom spontaneous decay rate. This indicates on superradiant coherent behavior of the atomic system inside the plasma.
In order to improve the sensitivity of online magnetic flux leakage (MFL) testing for steel pipe, a sensing method based on the magnetic guiding effect is proposed and investigated in this paper. Compared to the conventional contact sensing method using a non-ferromagnetic support, the proposed method creatively utilizes a ferromagnetic one to guide more magnetic flux to leak out. Based on Hopkinson’s law, the principle of the magnetic guiding effect of the ferromagnetic support is theoretically illustrated. Then, numerical simulations are conducted to investigate the MFL changes influenced by the ferromagnetic support. Finally, the probe based on the proposed method is designed and developed, and online MFL experiments are performed to validate the feasibility of the proposed method. Online tests show that the proposed sensing method can greatly improve the MFL sensitivity.
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