Multi-targeted interference-free determination of ten β-blockers in human urine and plasma samples by alternating trilinear decomposition algorithm-assisted liquid chromatography–mass spectrometry in full scan mode: Comparison with multiple reaction monitoring

Solving signal instability to maintain the second-order advantage in the resolution and determination of multi-analytes in complex systems by modeling liquid chromatography–mass spectrometry data using alternating trilinear decomposition method assisted with piecewise direct standardization

“…The average recoveries of six analytes (between 86.9 ± 3.9% and 104.8 ± 3.7%) demonstrated that relatively satisfactory results were obtained and the analytical strategy that combines three-way LC-MS data with ATLD method could be successfully applied to quantify multiple drugs in human plasma samples even in the presence of unknown interferences and seriously overlapped peaks. Even so, it should be emphasized again that all the above satisfactory results were obtained from the data registered in experiment 1 (data model 11) which suggested that the second-order calibration model based on ATLD method works very well when calibration standards and test samples are run together.…”

“…Attracted by this advantage, some interesting applications have been done in this context [8][9][10][11]. Gu et al presented a strategy that combined three-way LC-MS data with alternating trilinear decomposition (ATLD) method to simultaneously determine ten ␤-blocks in human urine and plasma samples [11]. They demonstrated that there are no statistically significant differences between the proposed methodology and MRM method.…”

“…This is well-known as the "second-order advantage" [6,7]. Attracted by this advantage, some interesting applications have been done in this context [8][9][10][11]. Gu et al presented a strategy that combined three-way LC-MS data with alternating trilinear decomposition (ATLD) method to simultaneously determine ten ␤-blocks in human urine and plasma samples [11].…”

Chemometrics-enhanced liquid chromatography-full scan-mass spectrometry for interference-free analysis of multi-class mycotoxins in complex cereal samples

“…1. In previous literature [26,27], similar strategies have been proved to be feasible for accurate and simultaneous determination of multiple analytes in other complex systems. However, new challenges occurring in the present investigation need to be further explored and discussed, e.g.…”

Second-order calibration method applied to process three-way excitation–emission-kinetic fluorescence data: A novel tool for real-time quantitative analysis of the lactone hydrolysis of irinotecan in human plasma

“…At the same time, several second-order calibration algorithms, such as parallel factor analysis-alternating least squares (PARAFAC-ALS) [28], alternating trilinear decomposition (ATLD) [29], multivariate curve resolution-alternating least squares (MCR-ALS) [30], and alternating normalization-weighted error (ANWE) algorithm [31] have been proposed. However, it is worth noting that there is not a single versatile method that is appropriate for all situations because every method has its own advantages and disadvantages [32], and the fields of application of these methods are not the same. Some reports have compared the properties of these methods from the perspectives of theory and application [33][34][35][36][37][38].…”