A B S T R A C T In order to study the splanchnic metabolism of blood-borne estrogens, a constant infusion of estrone-6,7-2H was made in a series of dogs, and arteriovenous (A-V) differences at equilibrium were determined for estrone-6,7-2H and for its products estradiol-17P, estrone estradiol-17,8 by the intestine, associated with substantial net production of estrone glucosiduronate. There is net uptake of estrone by the spleen and a small but significant net uptake of estrone glucosiduronate.
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