Investigation of a Radioimmunoassay for Plasma Estrone and Estradiol-17β in Males and Nonpregnant Females. Comparison with an Independent Method using Fluorimetry

Wright, K.; Robinson, Hugh; Collins, Delwood C.; Preedy, J. R. K.

doi:10.1210/jcem-36-1-165

Cited by 35 publications

(8 citation statements)

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“…Italy, have been previously described [1][2][3]. Concentrations of 17-[)-E: were measured by a specific RIA, with the use of polyethylene gly col to separate free and bound hormone, after a single diethylether extraction of samples [21], Analysis of variance (F test) was applied to establish whether variation between groups was higher than that observed within groups.…”

Section: Methodsmentioning

confidence: 99%

Relationships between Intracranial Pressure and Diurnal Prolactin Secretion in Primary Empty Sella

Maira¹,

Anile²,

Cioni³

et al. 1984

Neuroendocrinology

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The role of the intracranial pressure (ICP) in the development and/or maintenance of the primary empty sella has been evaluated by recording the ICP during sleeping and waking periods in 11 women who had this syndrome. Concomitantly, plasma PRL levels, measured at 2-hour intervals during a 24-hour period, were compared with the changes in ICP. Daily PRL variations were also measured in 5 normally cycling and 5 postmenopausal women. ICP was abnormally increased in 8 patients with PES. In 3 of them, increased values were recorded during waking and sleeping periods, while in 5 subjects abnormal values were observed only during sleep. In the remaining 3 patients the ICP was normal in all conditions tested. 8 patients with elevated ICP presented an absent or blunted nocturnal PRL increase. In 3 patients with normal ICP, the circadian periodicity of PRL was preserved. The normalization of ICP obtained in 4 patients by a surgical shunting procedure was accompanied by the return to normal of the circadian PRL periodicity. Our observations demonstrate that the finding of a normal ICP during wakefulness is not sufficient to rule out an actual increase in ICP, since a rise in the CRF pressure can occur during sleep. Our data also demonstrated a correlation between an abnormal rise in ICP and an absent or blunted nocturnal increment in PRL secretion.

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Section: Methodsmentioning

confidence: 99%

Relationships between Intracranial Pressure and Diurnal Prolactin Secretion in Primary Empty Sella

Maira¹,

Anile²,

Cioni³

et al. 1984

Neuroendocrinology

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“…Es trone and P-estradiol were determined as described by Wright et al [11], and estriol by using the method of Tulchinsky and Abraham [12].…”

Section: Measurement O F Estrogen Hormone Levelsmentioning

confidence: 99%

NK Cell Activity and Estrogen Hormone Levels during Normal Human Pregnancy

Gabrilovac

J²,

Osmak

et al. 1988

Gynecol Obstet Invest

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NK cell activity was determined in peripheral blood of 24 women during pregnancy, and compared to NK activity of 40 healthy nonpregnant women in generative age. An increase in the first trimester was followed by a significant decline of NK activity in the second trimester, and a further fall in the third trimester of pregnancy. The initial rise of NK activity was predominantly due to primigravidas, whereas the fall in the second trimester was mainly due to multigravidas. There was a significant negative correlation between NK activity and the increasing levels of estrogen hormones (β-estradiol, estriol and estrone) in the sera of pregnant women. However, when analyzed for each trimester of pregnancy separately, a significant (p < 0.02) negative correlation was only found with β-estradiol, suggesting that high doses of this hormone could contribute to pregnancy-associated NK suppression.

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“…The assay was performed in duplicates. The same method was also used by other investigators [12][13][14].…”

Section: Methodsmentioning

confidence: 99%

Hormonal Profile of Endometrial Cancer

Oettinger¹,

Samberg²,

Levitan³

et al. 1984

Gynecol Obstet Invest

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Out of all the risk factors of endometrial carcinoma, the Oestrone Theory’ is especially fascinating. This theory assumes that prolonged uninterrupted stimulation of the endometrial cell by oestrone, without the competition of oestradiol and oestriol, brings about neoplasia. There is also some evidence of a protective effect of androgens and progesterone. In order to verify this theory in vivo, oestrone (E₁), oestradiol (E₂), testosterone (T) and progestogen levels were examined from the serum of 36 post-menopausal women suffering from endometrial carcinoma, and compared with a healthy group of women. Oestrone levels were found to be significantly higher in patients with endometrial carcinoma. A correlation was also found between oestrone levels and previous infertility. With the intention of tracking the origin of oestrone in those suffering from endometrial cancer, hormone levels were checked before and after total hysterectomy and oophorectomy. The high oestrone values dropped to normal after the operation, except in those who had previously suffered from infertility. In those patients, high oestrone values were found a year after the operation. No significant differences of testosterone or progesterone were found between the cancer patients and the healthy women. The operation did not have any influence on these values.

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Investigation of a Radioimmunoassay for Plasma Estrone and Estradiol-17β in Males and Nonpregnant Females. Comparison with an Independent Method using Fluorimetry

Cited by 35 publications

References 0 publications

Relationships between Intracranial Pressure and Diurnal Prolactin Secretion in Primary Empty Sella

Relationships between Intracranial Pressure and Diurnal Prolactin Secretion in Primary Empty Sella

NK Cell Activity and Estrogen Hormone Levels during Normal Human Pregnancy

Hormonal Profile of Endometrial Cancer

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