Background: Chronic liver disease (CLD) is an important cause of morbidity and mortality and can lead to hepatic fibrosis. This study was conducted to evaluate the diagnostic value of real-time shear wave elastography (SWE) in the assessment of hepatic fibrosis. Methods: A systematic search of databases was performed for publications on SWE during the period between 2010 and 2017. The identified studies were analyzed using Meta-disc 1.4 software to integrate and analyze the data. Results: Eleven studies comprising 1560 patients were included for analysis. The pooled sensitivity, specificity and diagnostic odds ratio were 0.85 (95% CI: 0.82-0.87), 0.79 (95% CI: 0.76-0.82) and 30.81 (95% CI: 16.55-57.34), respectively for patients with a Metavir-score of ≥ F2; 0.87 (95% CI: 0.84-0.91), 0.84 (95% CI: 0.82-0.87), 41.45 (95% CI:18.25-94.45), respectively for patients with ≥ F3; 0.88(95% CI: 0.83-0.91), 0.91 (95% CI: 0.89-0.92), 67.18 (95% CI:30.02-150.31), respectively for patients with ≥ F4. The areas under the receiver operating characteristic curve of the three groups were 0.9147, 0.9223 and 0.9520, respectively. Conclusions: Our work demonstrates that SWE is highly accurate for detecting and staging hepatic fibrosis.
The reaction of Co(II) salt with 5-tert-butylbenzene-1,3-dicarboxylic acid (5-tert-H2IPA) and N,N′-bis(3-pyridyl) terephthalamide (L) in a mixed solvent of H2O and CH3CN affords a new coordination polymer [Co(L)0.5(5-tert-IPA)]n
(1). Based on the slow release of the drug, hydrogels loaded with Co(II) metal–organic frameworks of urinastatin were prepared. SEM images showed that the hydrogels had a highly porous morphology. Furthermore, the treatment activity of the hydrogels on sepsis acute lung injury
was assessed. ELISA detection results showed that the hydrogels significantly reduced the levels of the IL-6 and UL-18 released into the alveolar lavage fluid. The relative expression of the lncRNA NANCI in lung epithelial cells was also inhibited by the hydrogels in a dose-dependent manner.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.