Bioassay-directed isolation of the antitumor extract of Wikstroemia indica (Thymelaeaceae) has led to the characterization of tricin, kaempferol-3-O-beta-D-glucopyranoside, and (+)-nortrachelogenin as the major antileukemic constituents. In addition, daphnoretin was identified as the potent antitumor principle in vivo against the Ehrlich ascites carcinoma growth in mice.
The active extract of the seeds of Brucea jauanica has yielded bruceoside-A (1) and -B (2), two novel potent antileukemic quassinoid glycosides of bruceosin (15) and brusatol (8), respectively, as well as brucein-D (3) and -E (4).The structure and stereochemistry of these compounds have been established from chemical transformation, correlations, and spectral analyses.A three-step sequential procedure has been developed whereby a "one-pot'' reduction of aromatic ester groups directly to methyl is now possible. One of these steps involves conversion of the aromatic ester to a trimethylsilyloxy
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