Background Several evidences from epidemiologic and treatment studies indicate that anxiety disorders, depression, and substance use disorders commonly co-occur, and the interaction is multifaceted and variable. Epidemiological studies and investigations within clinical substance abuse populations have found an association between anxiety disorders, depression, and substance use disorders. Results The mean age was 28.1 ± 6.5 years. The majority belonged to the moderate socioeconomic status (52%). Substance use disorder (SUD) patients expressed higher levels of anxiety and depression in comparison to the control group. Most of the study group (97%) expressed different levels of anxiety. Eighty percent of them expressed high and moderate anxiety levels, and 20% of caregivers were having mild anxiety levels. Ninety-three percent of the substance users expressed different levels of depression, either mild 12%, moderate 9%, or severe 72%. The Drug Use Disorder Identification Test scores were positively correlated with anxiety (r = 0.256 and p = 0.010) and depression (r = 0.330 and p = 0.001). Moreover, it was found that anxiety and depression are positively correlated with each other’s (r = 0.630 and p = 0.001). Conclusion Substance use disorders are associated with high levels of anxiety and depression. More specifically, it is associated with severe depression and anxiety. There is an obvious association between the presence of anxiety and depression on the one hand and the severity of drug-related problems on the other hand. Depression and anxiety are commonly present together in patients with SUDs.

Background: Several studies using event-related potential (ERP) methods have reported a relationship between the cognitive dysfunction of patients with psychosis and P300 latency and amplitude. P300 follow-up studies in patients with schizophrenia receiving antipsychotic treatment revealed that the P300 amplitudes were increased while other studies showed limited changes in the P300 amplitude even after antipsychotics use. Results: We found that at the first presentation, all patients' groups have significantly lower amplitude and more prolonged latency of P300 than controls. All the first-episode psychosis patients showed a significant improvement of P300 amplitude mean scores after 1 year, but with no significant change in the P300 latency. There was an inverse correlation between the patients' PANSS scores and their P300 latency and amplitude values. Conclusion: P300 amplitude and latency might be of clinical value in the evaluation of cognitive functions in the first-episode psychosis patients. The abnormalities in P300 may be improved with continuous control of psychotic symptoms with psychotropic medications.

Objective:To determine some of the neuropsychiatric manifestations of systemic lupus erythematosus (SLE) by applying multimodal neurophysiological and psychometric studies.Patients and methods:Twenty-six SLE patients were evaluated for neurological and psychiatric disorders and compared with 26 healthy controls matched for age, sex, education, and social class. The severity of SLE disease was assessed. Each subject was subjected to the following examinations: laboratory, neurophysiology, magnetic resonance imaging of the brain, transcranial duplex, Modified Mini-mental State Examination, Cognitive Assessment Scale Inventory, Hamilton Depression Scale, and Hamilton Anxiety Scale.Results:The mean age of subjects was 25.9 ± 8.9 years. The most prevalent neurological manifestations were (in order of frequency) anxiety in 17 cases (65.4%), depression in 15 cases (57.7%), headache in 10 cases (38.5%), peripheral neuropathy in 7 cases (26.9%), seizures in 6 cases (23.1%), psychosis in 5 cases (19.2%), dementia in 4 cases (15.4%), radiculopathy in 4 cases (15.4%), myositis in 3 cases (11.5%), and stroke in 2 cases (7.7%). There was a significant affection in amplitude of the ulnar nerve, cognitive function impairment, and electroencephalography changes. There was a significant increased mean velocity and decreased Pulsatility Index of the most studied intracranial vessels in the patients.Conclusion:The use of multimodal neurophysiological, transcranial duplex, and psychometric scales increases the sensitivity for detecting nervous system involvement.

Psycho-educational program which enhanced health behaviors, increased coping skills, give information about what substance abuse is, and its complications on drug addict patients physical and mental health. Aim of the study: Evaluate the effect of psycho-educational program on depression among drug addict patients. Design: Quasi-Experimental pretest posttest controlled design was used. Subjects and method: The studied sample consisted of 100 drug addict patients, 50 were study group & 50 were control group. Tools: Personal data, pattern of drug addiction questionnaire, and Beck Depression Inventory (BDI). Results: pre psycho-educational program, the majority of drug addict patients had severe levels of depression while, post program, the drug addict patients (study group) had less levels of depression than control group who didn't received psycho-educational program. Conclusion: Psycho-educational program had positive effects on levels of depression among study group than control group. Recommendations: Psycho-educational program should be part of the treatment strategies among drug addict patients and their families.

Addiction is a social, health, economic and cultural harm and problem that have influenced the future sovereignty and security of countries. The interactions between anxiety, depression and drug addiction are complex, approximately 31% of depression and anxiety has been found among drug addict people in Egypt. Aim of the study: To assess levels of anxiety and depression, and assess the difference between levels of anxiety and depression among drug addict people. Subjects and method: Non experimental (case-control) research design used to conduct this study. The current study included 150 subjects, 100 were drug addict people & 50 were drug non-addict people. Tools of study included demographic and clinical data sheet, Drug Use Disorder Identification Test, Hamilton Anxiety Rating Scale, and Hamilton Depression Rating Scale Results: The majority of drug addict people had severe levels of anxiety and depression as compared to normal non-addict people. Using patterns and various drug related problems was positively and significantly correlated with anxiety (r=0.256&p=0.010*) and depression (r=0.330&p=0.001**). The present study can concluded that drug addict people had severe levels of anxiety and depression than drug non-addict people Recommendations: psychosocial counseling program for drug addict people to decrease depression and anxiety.