This article discusses recent advances in biocompatible and biodegradable polymer optical fiber (POF) for medical applications. First, the POF material and its optical properties are summarized. Then, several common optical fiber fabrication methods are thoroughly discussed. Following that, clinical applications of biocompatible and biodegradable POFs are discussed, including optogenetics, biosensing, drug delivery, and neural recording. Following that, biomedical applications expanded the specific functionalization of the material or fiber design. Different research or clinical applications necessitate the use of different equipment to achieve the desired results. Finally, the difficulty of implanting flexible fiber varies with its flexibility. We present our article in a clear and logical manner that will be useful to researchers seeking a broad perspective on the proposed topic. Overall, the content provides a comprehensive overview of biocompatible and biodegradable POFs, including previous breakthroughs, as well as recent advancements. Biodegradable optical fibers have numerous applications, opening up new avenues in biomedicine.

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A common-path parallel-quadrature on-axis phase-shifting interferometry using a modified Michelson configuration with a polarizing cube beam splitter is proposed for quantitative phase measurement. The frequency spectrum of the circularly polarized object beam is split into two beams using a beam splitter. One beam is converted to a 45° linearly polarized beam to act as the object beam, and the other beam is low-filtered by a pinhole mirror to act as the reference beam. Two interferograms with quadrature phase shift can be simultaneously captured by combining the 45° linearly polarized object beam with the circularly polarized reference beam through a 45° tilted polarizing cube beam splitter, and the phase of a specimen can be then retrieved through a two-step phase-shifting algorithm. Experiments are carried out to demonstrate the validity and stability of the proposed method.

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