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1 In a placebo controlled double-blind study including 10 patients with heart failure the nisoldipine/digoxin interaction was studied. 2 Nisoldipine was shown to elevate digoxin plasma concentrations significantly by about 15% (trough levels). 3 During chronic combination therapy with nisoldipine trough levels and plasma concentrations 4 h after the morning dose of digoxin were 1.35 ± 0.14 and 1.92 ± 0.16 ng ml-' respectively, whereas they averaged to 1.16 ± 0.14 and 1.52 + 0.16 ng ml-1 with digoxin and placebo (P < 0.05; mean + s.e. mean). 4 Systolic time intervals were significantly altered by nisoldipine co-administration compared with digoxin plus placebo. 5 In certain patients the elevation of digoxin plasma levels due to nisoldipine coadministration could be of clinical relevance.

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