1986
DOI: 10.1111/j.1365-2125.1986.tb05243.x
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Influence of nisoldipine on haemodynamic effects and plasma levels of digoxin.

Abstract: 1 In a placebo controlled double-blind study including 10 patients with heart failure the nisoldipine/digoxin interaction was studied. 2 Nisoldipine was shown to elevate digoxin plasma concentrations significantly by about 15% (trough levels). 3 During chronic combination therapy with nisoldipine trough levels and plasma concentrations 4 h after the morning dose of digoxin were 1.35 ± 0.14 and 1.92 ± 0.16 ng ml-' respectively, whereas they averaged to 1.16 ± 0.14 and 1.52 + 0.16 ng ml-1 with digoxin and placeb… Show more

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Cited by 23 publications
(7 citation statements)
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“…The estimated IC50 value for simvastatin on [ 3 H]digoxin transport in LLC-GA5-COL150 cells was 48.2 l m , which was higher than those of the Ca 2 + blockers, nicardipine (4.54 l m ), manidipine (4.65 l m ) and benidipine (4.96 l m ), and comparable with that of nisoldipine (44.1 l m ) (unpublished results). The interaction of nisoldipine with digoxin was observed in clinical use, but the degree of the interaction was not signi® cant (Kirch et al 1986). The plasma concentration of simvastatin (40 mg}day) was around 50 l g equiv.…”
Section: [ 3 H]digoxin Transport At 3 H ( % Of Dose)mentioning
confidence: 99%
“…The estimated IC50 value for simvastatin on [ 3 H]digoxin transport in LLC-GA5-COL150 cells was 48.2 l m , which was higher than those of the Ca 2 + blockers, nicardipine (4.54 l m ), manidipine (4.65 l m ) and benidipine (4.96 l m ), and comparable with that of nisoldipine (44.1 l m ) (unpublished results). The interaction of nisoldipine with digoxin was observed in clinical use, but the degree of the interaction was not signi® cant (Kirch et al 1986). The plasma concentration of simvastatin (40 mg}day) was around 50 l g equiv.…”
Section: [ 3 H]digoxin Transport At 3 H ( % Of Dose)mentioning
confidence: 99%
“…In a study by Kirch et al [79] trough plasma digoxin concentrations were elevated by about 15%. In a study by Kirch et al [79] trough plasma digoxin concentrations were elevated by about 15%.…”
Section: Nisoldipinementioning
confidence: 91%
“…[30] Coadministration of oral verapamil with oral atenolol [33] resulted in a variable increase in atenolol steady-state plasma concentrations in a group of patients receiving long term maintenance therapy with these 2 agents. These authors advocate limiting this combination to hospital practice because hospitalised patients can be more closely Kirch et al [79] Increase in digoxin concentration Continued over page McGourty et alf 34 ] noted improvement in the symptoms of angina pectoris in a high percentage of patients who were treated with both atenolol and verapamil, but a few patients developed congestive heart failure.…”
Section: 1 Afenololmentioning
confidence: 99%
“…Nisoldipine increases blood digoxin levels by about 16% to 20% [102]. Nisoldipine increases bioavailability of propranolol, presumably by increasing splanchnic blood flow and decreasing the rate of first-pass metabolism of propranolol [103].…”
Section: Drug Interactionsmentioning
confidence: 99%