Interaction Between Alcohol and Metoprolol or Atenolol in Social Drinking

Kirch, Wilhelm; Spahn, H.; Hutt, HJ; Ohnhaus, E. E.; Mutschler, E.

doi:10.2165/00003495-198300252-00047

Cited by 2 publications

(1 citation statement)

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“…this can increase the first-pass hepatic metabolism of orally ingested metoprolol and propranolol,[8.11] thereby decreasing ~-blocker bioavailability. !12] Accordingly, those ~-blockers which are predominantly excreted unchanged by the kidney (atenolol, nadolol and sotalol) would not be influenced by drug-induced changes in the hepatic cytochrome P450 system.l IO ,12] The second group of drug interactions are called pharmacodynamic interactions. These occur when the therapeutic or toxic effect of one drug is potentiated or enhanced by the pharmacological actions of another drug.…”

Section: Discussionmentioning

confidence: 99%

??-Blockers Drug Interactions of Clinical Significance

Blaufarb

Pfeifer²,

Frishman³

1995

Drug Safety

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The clinician prescribing beta-blockers for his or her patients is faced with an often difficult situation. There are many beta-blockers, each with its own pharmacological profile. Patients are often taking multiple medications, thus increasing the risk of both anticipated and unexpected drug interactions. Reports of drug interactions are frequently anecdotal. The prescriber may not be aware of the patient's other medications or lifestyle habits. Pharmacokinetic and pharmacodynamic drug interactions involving beta-blockers are documented in the literature, but these studies often examine small numbers of patients. For these reasons, it is difficult for the practitioner to distill guidelines for the administration of beta-blockers in conjunction with other medication. In general, beta-blockers are well tolerated, and symptomatic drug interactions are relatively infrequent. It is incumbent upon the clinical practitioner to have knowledge of his or her patient's drug profile and to be aware of the various drug interactions as well as each patient's unique pathophysiological profile when prescribing any medication, including beta-blockers. beta-Blockers may interact with a large number of commonly prescribed drugs, including antihypertensive and antianginal drugs, inotropic agents, anti-arrhythmics, NSAIDs, psychotropic drugs, anti-ulcer medications, anaesthetics, HMG-CoA reductase inhibitors, warfarin, oral hypoglycaemics and rifampicin (rifampin).

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Section: Discussionmentioning

confidence: 99%