Introduction: Aloe vera has been shown to have various biological and pharmacological effects like wound healing, anti-inflammatory effects, antibacterial and antiviral property, immunomodulating effects, and antioxidant property. Aim: The study was conducted to evaluate the efficacy of Aloe vera gel as local drug delivery agent for treatment of pockets in chronic periodontitis through clinical assessment. Materials and methods: A split-mouth designed study was conducted in 15 patients with total 30 sites, having bilateral mild to moderate periodontal pockets (5-7 mm). Following clinical parameters were recorded: probing pocket depth, gingival bleeding index, plaque index, and clinical attachment level for test group in which scaling and root planing (SRP) was done followed by placement of Aloe vera gel on day 0, 7, and 14 and in control group where only SRP was done. Results: All the clinical parameters showed significant difference on 30th day in both intragroup and intergroup. Conclusion: The use of Aloe vera gel resulted in more clinical improvements when compared with control group. Thus, it can be stated that Aloe vera shows promising future as local drug delivery in both preventive and therapeutic treatments available for chronic periodontitis.
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