Background: Several drugs are used for the management of hypertension. Among these drugs, calcium channel blockers (CCBs) are the most potent and generally used drug. Gingival enlargement is a recognized outcome of the administration of CCBs. Other drugs which cause gingival enlargement are antiepileptic drugs (phenytoin) and immunosuppressants (cyclosporine). The role of bacterial plaque in the overall pathogenesis of drug-induced gingival enlargement is not clear as some studies indicate that plaque is a prerequisite for gingival enlargement, whereas others suggest that the presence of plaque is a result of its accumulation caused by the enlarged gingiva. Aim: The aim of this study is to find the association of local factors with CCBs-induced gingival enlargement. Conclusion:The observations made in this report support that the presence of local factors augments the degree of the gingival enlargement present. Significance: As the prevalence of CCB use is relatively high in the population, especially among patients with cardiovascular disease, it is important that medical professionals are aware of the association between drug-induced gingival enlargement and local factors so that they can emphasize thorough home care and professional cleaning in the treatment of drug-induced gingival enlargement.
Background: Chemomechanical caries removal (CMCR) is a noninvasive procedure that uses a chemical substance to remove the diseased dentin. The natural dental architecture is also preserved using this technique, preventing patient discomfort and pulp irritation. This method of eliminating caries is based on disintegration. This method removes soft carious dentin using chemical agents and non-traumatic mechanical force. This study was carried out to evaluate the clinical and microbiological evaluation of the chemomechanical caries removal agents in primary molars.Methods: For the elimination of caries, teeth in category I (polymer bur category) were treated with Smartburs II® (SS White Dental, Lakewood, New Jersey, United States) (n = 40). Teeth treated with the new Carisolv® technology (Mediteam, Sweden) to remove caries (n = 40). Teeth were treated for removal cavities in category III (conventional group) using excavators and carbon steel low-speed round burs from Dentsply Maillefer in Switzerland (n = 40). There was an evaluation of the efficacy of caries removal, the time required for caries removal, patient satisfaction, and microbial culture assessment.Results: In comparison to the other two categories, the conventional category median caries detector dye values were considerably lower (p value<0.05). There was no substantial difference observed between study participants belonging to category I and category II with a p-value greater than 0.05. Time taken during the removal of caries was substantially greater in category I (455.46±73.7) as compared to category II (129.21±44.18) and the traditional category (113.26±37.7). The value of significance was less than 0.05. Contrarily, no discernible difference was observed between category I and category III (the p-value was greater than 0.05). In comparison to the other two categories, the conventional group's median facial expression scale scores were substantially higher (p = 0.02). In comparison, there was no discernible difference between categories I and II (p = 0.65). It was observed that there was no substantial variation in three categories regarding the number of colonies of bacteria prior to the eradication of caries (p-value greater than 0.05). After caries had been removed, the number of living bacterial colonies in category I was noticeably greater than those in the other two categories. However, there was no discernible variation between category II and category 1 (p-value greater than 0.05). Conclusion:The mechanical approach has the highest clinical efficacy for removing caries. Carisolv required the most time to remove cavities. Patient satisfaction levels were greater with Carisolv than with the mechanical approach. It was also observed that Carisolv as well as the mechanical technique had greater antibacterial effectiveness.
Introduction: Aloe vera has been shown to have various biological and pharmacological effects like wound healing, anti-inflammatory effects, antibacterial and antiviral property, immunomodulating effects, and antioxidant property. Aim: The study was conducted to evaluate the efficacy of Aloe vera gel as local drug delivery agent for treatment of pockets in chronic periodontitis through clinical assessment. Materials and methods: A split-mouth designed study was conducted in 15 patients with total 30 sites, having bilateral mild to moderate periodontal pockets (5-7 mm). Following clinical parameters were recorded: probing pocket depth, gingival bleeding index, plaque index, and clinical attachment level for test group in which scaling and root planing (SRP) was done followed by placement of Aloe vera gel on day 0, 7, and 14 and in control group where only SRP was done. Results: All the clinical parameters showed significant difference on 30th day in both intragroup and intergroup. Conclusion: The use of Aloe vera gel resulted in more clinical improvements when compared with control group. Thus, it can be stated that Aloe vera shows promising future as local drug delivery in both preventive and therapeutic treatments available for chronic periodontitis.
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