Several studies have suggested that selenium serum levels may be associated with serum lipids and apolipoproteins. In the present study, 99 clerical workers aged 40-49 yr were selected based on their drinking and smoking habits. The serum concentration of selenium was not affected by these lifestyle factors. The regular drinkers had raised serum high-density lipoprotein cholesterol, apo A-I, and apo A-II concentrations. Correlation analysis showed that serum selenium was positively and consistently associated with apo A-II regardless of alcohol consumption. Factor analysis revealed that serum selenium had no association with factors that represented each lipoprotein fraction (LDL, HDL, and VLDL). The present study indicates that serum selenium is positively correlated only with apo A-II levels.
SummaryThe relationships of cigarette smoking, exercise, and body mass index (BMI) to the serum levels of high-density lipoprotein (HDL) cholesterol, apolipoprotein AI (Apo AI), apolipoprotein All (Apo All), and % of HDL cholesterol to total cholesterol (%HDL-C) were assessed in 495 employees of a telephone company in Japan. They were subdivided into four groups by frequency of alcohol intake: nondrinkers (n=28), those who drank once per week (n=78), those who drank 2 to 5 times per week (n=245), and those who drank 6 to 7 times per week (n=144). Although univariate analysis before grouping showed a positive correla tion between Apo All and BMI, multiple analysis examined in each group showed the positive relationship only in the nondrinking group. The relationship between BMI and Apo AII would thus appear to depend on drinking habits.
The relationship of serum zinc with serum concentrations of lipids and apolipoproteins was investigated in 464 male clerical workers aged 35-59 y. Subjects were divided into three groups, by drinking habits. Serum triglycerides, apolipoprotein (apo) A-I, and apo A-II in occasional (2-5 times/wk) and regular (> or = 6 times/wk) drinkers were higher than in non- or seldom (< 1 time/wk) drinkers, whereas serum zinc, total cholesterol (TC), and apo B were not different among groups. Significantly higher high-density-lipoprotein cholesterol (HDL-C) and HDL-C% (HDL-C/TC%) were observed in regular drinkers. Correlation analysis revealed that the serum zinc concentration was positively correlated with apo A-II only in the regular drinkers, and the relationship was significant even after body mass index, smoking habits, and frequency of physical exercise were adjusted for. The results suggest that the individual response of the apo A-II concentration to alcohol is associated with zinc nutritional status in regularly drinking middle-aged men.
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