Drug-drug interaction (DDI) is a specific type of adverse event, which developsdue to multiple regimen therapy, and that may lead to significant hospitalization and death.Clinical and economic impact of drug interactions are increasingly accredited as a chiefconcern in critical care. Potentiating effects of DDIs in intensive care units are far more criticaldue to complex medications regimen, high risk severely ill population and associated metabolicand physiological disturbances which can impede drug effects. Pharmacist contribution isclassified as clarification of drug order, appropriate drug information provision, and advice forsubstitute treatment. A multidisciplinary approach is very necessary in developing a pharmacotherapeuticregimen designed to optimize patient outcome and minimize any potential dugdrug interactions. This review encompasses the prevalence, categorization, significance interm of patient safety and prescription efficacy, clinical and economic burdens, national andinternational data comparisons related to drug-drug interactions.
REVIEW PROF-3670ABSTRACT… Drug-drug interaction (DDI) is a specific type of adverse event, which develops due to multiple regimen therapy, and that may lead to significant hospitalization and death. Clinical and economic impact of drug interactions are increasingly accredited as a chief concern in critical care. Potentiating effects of DDIs in intensive care units are far more critical due to complex medications regimen, high risk severely ill population and associated metabolic and physiological disturbances which can impede drug effects. Pharmacist contribution is classified as clarification of drug order, appropriate drug information provision, and advice for substitute treatment. A multidisciplinary approach is very necessary in developing a pharmacotherapeutic regimen designed to optimize patient outcome and minimize any potential dug drug interactions. This review encompasses the prevalence, categorization, significance in term of patient safety and prescription efficacy, clinical and economic burdens, national and international data comparisons related to drug-drug interactions. Key words:Drug-drug interactions, clinical and economic impact, significance, patient safety.
The solution for safe and rational medication use to improve patient care as well as to enhance public health status is Pharmacovigilance (PV). Optimal care of patient and appropriate medication utilization in secure way with respect to various conditions is an imperative function of pharmacovigilance system. PV mainly involves in the adverse drug reactions (ADRs) identification, system of reporting, scrutinizes the effectiveness of treatment, reduces the adverse consequences to utmost level and guarantees the patient wellbeing. The safety of drug is highly essential factor when it comes from the healthcare provider to the patient. For a drug to be successful in market, it is crucial for it to be efficacious as well as safe and secure for the patients. Hence, adherence toward pharmacovigilance activities and system is now based on a paradigm change from care to safety.
<p><strong>Objective: </strong>A qualitative, cross-sectional survey-based study was conducted to evaluate the integration of community setup in pharmaceutical care with respect to current challenges, awareness/perception of individuals from various walks of life, related facts and opportunities which are contextual to local settings in Karachi, Pakistan.</p><p><strong>Methods: </strong>This cross-sectional, a qualitative study, was conducted between May–November 2015. A questionnaire was designed using 15 close ended and 5 open-ended questions. And validated using correlation of spearman coefficient and Cronbach’s α value (α = 0.916 and <em>p</em> = 0.941). Local residents, pharmacist, medical practitioners, and pharmacy technicians were selected as study participants. Informed consents of all respondents were obtained prior to the participation.<strong> </strong>SPSS 20.0 was utilized and results were calculated with respect to percentages of responses and mean scores. Chi-square test was used to analyze the problems associated in effective implementation and integration of community pharmacy practices in Pakistan. <strong></strong></p><p><strong>Results: </strong>Rate of response in the various cohort were in the order of 76%, 94%, 71% and 83% for local residents, pharmacist, physicians and pharmacy technicians respectively. Community pharmacy knowledge and beliefs mean scores were correspondingly found to be 1.971.83, 1.457.44, 2.842.10 and 2.385.54 for doctors, pharmacist, residents and technicians respectively.</p><p><strong>Conclusion: </strong>A significant difference in the level of perception was observed amongst the professionals and local resident’s cohort, which necessitates the effective and better execution of community residents counseling and more stringent implementation of health care facilities at the community level to improve the medication and health outcomes of related inhabitants.</p>
Diclofenac potassium is efficiently utilized in treating pain during migraine, episodictension headache, ankle sprain, osteoarthritis and dental pain etc. This review article covers theclinical aspects, pharmacokinetics, different therapeutic applications, drug-drug interactions,related adverse effects, safety and efficacy of diclofenac potassium.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.
hi@scite.ai
10624 S. Eastern Ave., Ste. A-614
Henderson, NV 89052, USA
Copyright © 2024 scite LLC. All rights reserved.
Made with 💙 for researchers
Part of the Research Solutions Family.