Diclofenac Potassium

Ali, Huma; Zafar, Farya; Baloch, Saba Ajaz; Hasnain, Hina; Naveed, Safila; Naqvi, Ghazala Raza

doi:10.29309/tpmj/2016.23.04.1505

Cited by 2 publications

(3 citation statements)

References 18 publications

(12 reference statements)

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“…Interestingly, diclofenac can be one of the new k channel openers that activate KCNQ2\Q3 channels and this new mechanism of action can be helpful in epilepsy [33]. Anticonvulsant response by increasing KCNQ2/Q3 potassium currents makes it suitable for use in migraine epilepsy and neuropathy [15]. Al-Hayder et al found in rats they administered naproxen and diclofenac that 50 mg/kg diclofenac caused less damage to kidneys than 50 mg/kg naproxen [34].…”

Section: Discussionmentioning

confidence: 99%

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Histopathological effects on kidney of diclofenac potassium and diazepam used in an experimental epilepsy model

Şaylan¹,

Turel²,

Türel³

et al. 2023

j-ebr

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To investigate the effects of diazepam, which has anticonvulsant and anxiolytic effects, and diclofenac potassium, which has anti-inflammatory, analgesic and antipyretic effects, on rat kidney tissue, used in an experimental epilepsy model. Methods: 32 Wistar albino rats (2-4 months old, 200-250 gr) were used in the study. The rats were grouped in four as 8 rats in each group: Epilepsy, Epilepsy + Diazepam, Epilepsy + Diclofenac potassium, Epilepsy + Diazepam + Diclofenac potassium. Epileptic seizure model was created with penicillin (500.000 IU) injected intracortically under urethane anesthesia. 30 minutes later, diazepam (0.1 mg/kg) and diclofenac potassium (10 mg/kg) were administered intraperitoneally. At the end of the study, rat kidneys were removed and evaluated histopathologically in terms of inflammation, glomerular shrinkage, tubular dilatation, tubular epithelial thinning, desquame epithelium, brush epithelial loss, vacuolization, hemorrhage and congestion. Results: No difference was found between diazepam and diclofenac potassium in terms of vacuolization, glomerular shrinkage, tubular dilatation and hemorrhage. Inflammation, congestion and tubular epithelial thinning rate were found to be lower inEpilepsy + Diclofenac potassium and Epilepsy + Diazepam + Diclofenac potassium group when compared with Epilepsy + Diazepam group. While brush epithelial loss and desquame epithelial rate was found to be lowest in the epilepsy group, these parameters were not found to show a significant difference between drug groups. Conclusion: It was concluded that combined use of diazepam and diclofenac potassium in their effects on kidney are more useful than their single use.

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Section: Discussionmentioning

confidence: 99%

“…It is a benzene acetic acid derivative showing COX-2 enzyme inhibition. Chemical name for diclofenac potassium is 2-[(2,6dichlorophenyl)amino]-benzene acetic acid [15]. It has a quick elimination rate and a two-hour biological half-life [14].…”

mentioning

confidence: 99%

Histopathological effects on kidney of diclofenac potassium and diazepam used in an experimental epilepsy model

Şaylan¹,

Turel²,

Türel³

et al. 2023

j-ebr

View full text Add to dashboard Cite

show abstract

“…Its analgesic effect is attributed to a powerful inhibition of COX 2, exhibiting some selectivity for this enzyme so that inflammatory prostaglandins are no longer produced 12 . Available in oral, topical and injectable formulations, the drug is used both on a short term as well as long term basis for treating a number of ailments both in children and in adults 13 . NSAIDs also block thromboxane A2 synthesis, but inhibition is competitive and reversible.…”

Section: Introductionmentioning

confidence: 99%

Effect of Diclofenac Sodium on Aspirin’s Antithrombotic Role

Qaisrani,

Shabana Ali,

Salman Bakhtiar

et al. 2018

PAFMJ

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Objective: To assess whether diclofenac sodium interferes with the anti-platelet effect of low dose aspirin. Study Design: Quasi- experimental study. Place and Duration of Study: Department of Pharmacology and Therapeutics, Army Medical College and ArmedForces Institute of Pathology Rawalpindi. Material and Methods: Eighteen healthy volunteers, divided into three groups, between the ages of 22-50 years, after written informed consent were selected according to a set criterion. They were given aspirin (150mg) once a day and diclofenac sodium 50mg three times a day for six consecutive days while use of any other drug was prohibited. Blood samples were taken from the study subjects on two occasions, before starting drugs and then on the seventh day. Blood samples were analyzed for platelet aggregation (ADP and collagen induced) and serum thromboxane B2 levels. Results: When a single daily dose of 150mg aspirin is taken with three daily doses of diclofenac sodium (50mg), results show that the anti-platelet effect of aspirin still remains. The mean platelet aggregation with ADP was reduced to 55.83 ± 5.38 percent from a baseline value of 71.67 ± 5.27 percent. Similarly if collagen was used as a reagent the aggregation of platelets was markedly reduced to 40.83 ± 6.63 from a baseline of 66.67 ± 6.54 percent.Results showed a prominent inhibition of aggregation of 22.10% for ADP and 38.75% for collagen. Also, mean thromboxane B2 levels reduced markedly from 971.11 ± 128.91 pg/ml to 702.99 ± 101.59 pg/ml. Conclusion: It is safe to use diclofenac sodium with aspirin, as the anti-platelet effect of the latter is not attenuated.

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Diclofenac Potassium

Cited by 2 publications

References 18 publications

Histopathological effects on kidney of diclofenac potassium and diazepam used in an experimental epilepsy model

Histopathological effects on kidney of diclofenac potassium and diazepam used in an experimental epilepsy model

Effect of Diclofenac Sodium on Aspirin’s Antithrombotic Role

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