Sano K, Yoshida S, Ninomiya H, Ikeda H, Ueno K, Sekine J, Iwamoto H, Uehara M, Inokuchi T: Assessment of growth potential by MIB‐1 immunohistochemistry in ameloblastic fibroma and related lesions of the jaws compared with ameloblastic fibrosarcoma. J Oral Pathol Med 1998; 27: 59–63. © Munksgaard, 1998. Specimens from two ameloblastic fibromas (including one recurrent case), two ameloblastic fibro‐odontomas, and one ameloblastic fibrosarcoma were subjected to investigation by MIB‐1 immunohistochemistry in order to elucidate the growth potential of these tumors. MIB‐1 labeling indices in the epithelial component of these tumors ranged from 2.9 to 7.5%, whereas those in the mesenchymal component ranged from 1.5 to 13.5%. Of these, labeling indices in the mesenchymal component of the recurrent ameloblastic fibroma and ameloblastic fibrosarcoma were quite high. These findings suggest that evaluation of growth potential in ameloblastic fibroma and related lesions could be of help in understanding tumor aggressiveness and in selecting appropriate surgical procedures.

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The aim of this study was to assess the healing response to the bone implants treated by heating or freezing. Allogenic calvarial implants treated by heating at 65˚C for 1 hour, 3 freezes of 3 minutes, or boiling for 10 minutes (65˚C, frozen and boiled group respectively) were tested for the potential to fill cranial bone defects of rabbits. Both the 65˚C and frozen groups similarly showed more than 60% of new bone formation in terms of the untreated control. Among the three treatment modalities, boiling presented the most remarkable impairment on the reparative capacity of the implants. The autogenous bone segments reimplanted to their original mandibular sites after treatment by heating at 65˚C using microwave or by freezing were revealed to similarly incorporate to the host bone in dog experiments. In summary, heat treatment at 65˚C for 1 hour is comparable with freeze treatment in terms of preservation of the regenerative potential of bone for simultaneous reimplantation.